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Toxoplasma skin- and dye-test surveys of severely subnormal patients in Lincolnshire*

Published online by Cambridge University Press:  15 May 2009

J. S. Robertson
J. S. Robertson
Affiliation:
50 Holydyke, Barton-on-Humber
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Of 918 severely subnormal patients in mental deficiency hospitals in Lincolnshire 917 were tested by the toxoplasmin skin tests, forty-nine out of 265 patients were dye tested because of a positive skin test or other indication. All patients in another group of 655 subnormals were dye tested, and comparison of these results with those of groups from the normal population showed that in children there was an excess of about 20% of dye-test positivity among the subnormals—a figure identical with that found by Thalhammer in Vienna.

The excess of positives became progressively less with increasing age and by middle age the incidence was the same in subnormals as among blood donors in the county. It is suggested that this indicates that patients in hospital are exposed to a lower risk of acquiring infection and that the higher incidence among adult males than among adult female defectives is due to the fact that more of them go out to work, many of them on farms. This factor could also explain the lower incidence of positivity in adult mongols and epileptics who are less commonly employable.

Possible explanations of the higher incidence among subnormal than among control children are discussed. Although it is tempting to assume that it indicates that some may be cases of congenital toxoplasmosis, the lack of gradient between child mongols, child epileptics and other subnormal children does not support this hypothesis. The numbers of mongol and epileptic children were too small to give statistically significant results. It is possible that the home environments of severely subnormal children exposed them to a higher risk of infection than did the homes of the control children and that the observed excess of dye and skin-test positivity may be due to increased incidence of acquired infection before their admission to hospital.

It was found that there was reasonable concordance between the dye test at a titre of 1/8 and skin sensitivity reactions exceeding 7 mm. in diameter, but poor agreement if 10 mm. was taken as the criterion of positivity.

Despite the lesser sensitivity of the skin test, the pattern of the results was the same as that observed in the dye-test survey, and the value of the skin-test for epidemiological surveys was confirmed.

Type
Research Article
Information
Journal of Hygiene , Volume 63 , Issue 1 , March 1965 , pp. 89 - 98
Copyright
Copyright © Cambridge University Press 1965

References

Beattie, C. P. (1957). Clinical and epidemiological aspects of toxoplasmosis. Trans. R. Soc. trop. Med. Hyg. 51, 96.Google Scholar
Beattie, C. P. (1958). Toxoplasmosis: a general introduction. Trans, ophthal. Soc. U.K. 78, 99.Google ScholarPubMed
Burkinshaw, J., Kirman, B. H. & Sorsby, A. (1953). Toxoplasmosis in relation to mental deficiency. Brit. med. J. i, 702.Google Scholar
Butler, E. N. (1959). Toxoplasmosis. Mon. Bull. Minist. Hlth Lab. Serv. 18, 180.Google ScholarPubMed
Cook, I. & Derrick, E. H. (1961). The incidence of toxoplasma antibodies in mental hospital patients. Australas. Ann. Med. 10, 137.CrossRefGoogle ScholarPubMed
Fair, J. R. (1959). Congenital toxoplasmosis. IV. Case finding using the skin-test and ophthalmoscope in state schools for mentally retarded children. Amer. J. Ophthal. 48, 813.Google Scholar
Feldman, H. A. (1958). Toxoplasmosis. Pediatrics, Springfield, 22, 559.Google ScholarPubMed
Fleck, D. G. (1963). Epidemiology of toxoplasmosis. J. Hyg., Camb., 61, 61.Google Scholar
Ira, Indrich (1960). Results of the study of toxoplasmosis in Czechoslovakia. J. Microbiol. Epidem. Immunobiol., 31, 1668.Google Scholar
Robertson, J. S. (1960). Excessive perinatal mortality in a small town associated with evidence of toxoplasmosis. Brit. med. J. ii, 91.CrossRefGoogle Scholar
Robertson, J. S. (1962). Toxoplasmosis. Devel. Med. Child Neurol. 4, 507.CrossRefGoogle ScholarPubMed
Sabin, A. B. (1942). ‘De Sanctis’. Advanc. Pediat. 1, 11.Google Scholar
Thalhammer, O. (1962). Congential toxoplasmosis. Lancet, i, 23.CrossRefGoogle Scholar