Hostname: page-component-745bb68f8f-b6zl4 Total loading time: 0 Render date: 2025-01-11T21:59:43.964Z Has data issue: false hasContentIssue false
  • English
  • Français

Towards a hepatitis A vaccine. A review

Published online by Cambridge University Press:  19 October 2009

B. N. Anderson ,
A. G. Coulepis  and
I. D. Gust
B. N. Anderson
Affiliation:
Virus Laboratory, Fairfield Infectious Diseases Hospital, Fairfield, Victoria 3078, Australia
A. G. Coulepis
Affiliation:
Virus Laboratory, Fairfield Infectious Diseases Hospital, Fairfield, Victoria 3078, Australia
I. D. Gust
Affiliation:
Virus Laboratory, Fairfield Infectious Diseases Hospital, Fairfield, Victoria 3078, Australia
Rights & Permissions [Opens in a new window]

Extract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Hepatitis A is an acute inflammation of the liver caused by a virus (HAV) whose morphology and physical characteristics resemble members of the enterovirus group. The disease, which is characterized by fever, malaise, anorexia, nausea, abdominal discomfort and jaundice has an average incubation period of 28–30 days and is spread from person to person by the faecal-oral route. Common-vehicle outbreaks have been reported following contamination of food or water and epidemics may occur in closed communities (institutions, day-care centres) or in the general community when there is a breakdown of environmental sanitation. Many infections, especially in children, are subclinical; the case fatility rate for patients requiring hospitalization is low and long-term sequelae are unknown.

Type
Research Article
Information
Journal of Hygiene , Volume 93 , Issue 2 , October 1984 , pp. 269 - 276
Copyright
Copyright © Cambridge University Press 1984

References

Baroudy, B. M., Ticehurst, J. R., Miele, T., Maizel, J. V., Puroell, R. H. & Feinstone, S. M. (1984). Sequence analysis of cloned hepatitis A virus (HAV) cDNA. In Proceedings of the 1984 International Symposium on Viral Hepatitis. New York: Grune & Stratton.Google Scholar
Bittle, J. L., Houghton, R. A., Alexander, H., Shinnick, T. M., Sutcliffe, J. G.& Lerner, R. A. (1982). Protection against foot-and-mouth disease by immunization with a chemically synthesized peptide predicted from the viral nucleotide sequence. Nature 298, 30–33.CrossRefGoogle ScholarPubMed
Centre for Disease Control (1983). Annual summary 1982: reported morbidity and mortality in the United States. Morbidity and Mortality Weekly Report 31, 34–37.Google Scholar
Coulepis, A. G.Locarnini, S. A., Lehmann, N. I.& Gust, I. D. (1980). Detection of a hepatitis A virus in the faeces of patients with naturally acquired infections. Journal of Infectious Diseases 141, 151–156.Google Scholar
Coulepis, A. G., Locarnini, S. A., Westway, E. G., Tannock, G. A. & Gust, I. D. (1982). Biophysical and biochemical characterization of hepatitis A virus. Intervirology 18, 107–127.CrossRefGoogle ScholarPubMed
Daemer, R. J., Feinstone, S. M., Gust, I. D. & Purcell, R. H. (1981). Propagation of human hepatitis A virus in African green monkey cell culture: primary isolation and serial passage. Infection and Immunity 32, 388–393.Google Scholar
Deinhardt, F., Holmes, A. W., Capps, R. B. & Popper, H. (1967). Studies on the transmission of human viral hepatitis to marmoset monkeys. 1. Transmission of disease, serial passages and description of liver lesions. Journal of Experimental Medicine 125, 673–688.CrossRefGoogle Scholar
Feinstone, S. M., Kapikian, A. Z. & Purcell, R. H. (1973). Hepatitis A: detection by immune electron microscopy of a virus-like antigen associated with acute illness. Science 182, 1026–1028.CrossRefGoogle Scholar
Feinstone, S. M., Alter, H. J., Dienes, H. P., Shimuzu, Y., Popper, H., Blackmore, D., Sly, D., London, W. T. & Puroell, R. H. (1981). Non-A, non-B hepatitis in chimpanzees and marmosets. Journal of Infectious Diseases 144, 588–598.Google Scholar
Feinstone, S. M., Daemer, R. J., Gust, I. D. & Purcell, R. H. (1983). Live attenuated vaccine for hepatitis A. Developments in Biological Standardization 54, 429–432.Google Scholar
Flehmig, B. (1980). Hepatitis A virus in cell culture. I. Propagation of different hepatitis A virus isolates in a fetal rhesus monkey kidney cell line (FRhK-4). Medical Microbiology and Immunology 168, 239–248.CrossRefGoogle Scholar
Frosner, G. G., Deinhardt, F., Scheid, R., Gauss-Muller, V., Holmes, N., Messelberger, V., Siegl, G. & Alexander, J. J. (1979). Propagation of human hepatitis A virus in a hepatoma cell line. Infection 7, 303–305.Google Scholar
Gauss-Muller, V., Frosner, G. G. & Deinhardt, F. (1981). Propagation of hepatitis A virus in human embryo fibroblasts. Journal of Medical Virology 7, 233–239.CrossRefGoogle ScholarPubMed
Gravelle, C. R., Hornbeck, C. L., Maynard, J. E., Schable, C. A., Cook, E. H. & Bradley, D. W. (1975). Hepatitis A: report of a common-source outbreak with recovery of a possible etiologic agent. Journal of Infectious Diseases 131, 167–171.CrossRefGoogle ScholarPubMed
Gust, I. D. (1982). Comparison of the epidemiology of hepatitis A and B. In Viral Hepatitis (ed. Szmuness, W., Alter, H. J. and Maynard, J. E., pp. 129–143. Philadelphia: the Franklin Institute Press.Google Scholar
Gust, I. D., Coulepis, A. G., Feinstone, S. M., Locarnini, S. A., Moritsugu, Y., Najera, R. & Siegl, G. (1983). Taxonomic classification of hepatitis A virus. Intervirology 20, 1–7.Google Scholar
Kleid, D. G., Yansura, D., Small, B., Dowbenko, D., Moore, D. M., Grubman, M. J., McKercher, P. D., Morgan, D. O., Robertson, B. H. & Bachrach, H. L. (1981). Cloned viral protein vaccine for foot-and-mouth disease: responses in cattle and swine. Science 214, 1125–1129.CrossRefGoogle ScholarPubMed
Linemeyer, D. L., Mitra, S. W., Hughes, J., Bennet, C. D., Menka, J. G. & Young, A. (1984). Molecular cloning of hepatitis A virus. In Proceedings of the 1984 International Symposium on Viral Hepatitis. New York: Grune & Stratton.Google Scholar
Locarnini, S. A., Ferris, A. A., Stott, A. C. & Gust, I. D. (1974). The relationship between a 27 nm virus-like particle and hepatitis A as demonstrated by immune electron microscopy. Intervirology 4, 110–118.CrossRefGoogle ScholarPubMed
Locarnini, S. A., Coulepis, A. G., Stratton, A. M., Kaldor, J. & Gust, I. D. (1979). Solid-phase enzyme-linked immunosorbent assay for detection of hepatitis A specific immunoglobulin M. Journal of Clinical Microbiology 9, 459–465.CrossRefGoogle ScholarPubMed
Locarnini, S. A., Coulepis, A. G., Kaldor, J. & Gust, I. D. (1980). Coproantibodies in hepatitis A: detection by enzyme-linked immunosorbent assay and immune electron microscopy. Journal of Clinical Microbiology 11, 710–716.CrossRefGoogle ScholarPubMed
Mascoli, C. C., Ittknsohn, O. L., Villarejos, V. M., Arguedas, J. A., Provost, P. J. & Hilleman, M. R. (1973). Recovery of hepatitis agents in the marmoset from human cases occurring in Costa Rica. Proceedings of the Society for Experimental Biology and Medicine 142, 276–282.CrossRefGoogle ScholarPubMed
Mathiesen, L. R., Feinstone, S. M., Wong, D. C., Skinhoej, P. & Purcell, R. H. (1978). Enzyme-linked immunosorbent assay for detection of hepatitis A antigen in stool and antibody to hepatitis A antigen in sera; comparison with solid-phase radioimmunoassay, immune electron microscopy and immune adherence hemagglutination assay. Journal of Clinical Microbiology 7, 184–193.CrossRefGoogle ScholarPubMed
Maynard, J. E., Bradley, D. W., Gravelle, C. R., Ebert, J. W. & Krushak, D. H. (1975). Preliminary studies of hepatitis A in chimpanzees. Journal of Infectious Diseases 131, 194–197.CrossRefGoogle ScholarPubMed
Miller, W. J., Provost, P. J., McAleer, W. J., Ittensohn, O. L., Villarejos, V. M. & Hilleman, M. R. (1975). Specific immune adherence assay for human hepatitis A antibody. Application to diagnostic and epidemiologic investigations. Proceedings of the Society for Experimental Biology and Medicine 149, 254–261.CrossRefGoogle ScholarPubMed
Panicali, D., Davis, S. W., Weinrurg, R. L. & Paoletti, E. (1983). Construction of live vaccines by using genetically engineered poxviruses: biological activity of recombinant vaccinia virus expressing influenza virus hemagglutinin. Proceedings of the National Academy of Sciences (USA) 80, 5364–5368.Google Scholar
Provost, P. J., Ittensohn, O. L., Villarejos, V. M. & Hilleman, M. R. (1975). A specific complement fixation test for human hepatitis A employing CR326 virus antigen. Diagnosis and epidemiology. Proceedings of the Society for Experimental Biology and Medicine 148, 962–969.CrossRefGoogle Scholar
Provost, P. J. & Hilleman, M. R. (1978). An inactivated hepatitis A virus vaccine prepared from infected marmoset liver. Proceedings of the Society for Experimental Biology and Medicine 159, 201–203.Google Scholar
Provost, P. J. & Hilleman, M. R. (1979). Preparation of human hepatitis A virus in cell culture in vitro. Proceedings of the Society for Experimental Biology and Medicine 160, 213–221.Google Scholar
Provost, P. J., Baker, F. S., Giesa, P. A., McAleer, W. J., Buynak, E. S. & Hilleman, M. R. (1982). Progress towards a live attenuated human hepatitis vaccine. Proceedings of the Society for Experimental Biology and Medicine 170, 8–14.CrossRefGoogle Scholar
Provost, P. J., Conti, P. A., Giesa, P. A., Banker, F. S., Buynak, E. B., McAleer, W. J. & Hilleman, M. R. (1983). Studies in chimpanzees of live, attenuated hepatitis A vaccine candidates. Proceedings of the Society for Experimental Biology and Medicine 172, 357–363.Google Scholar
Purcell, R. H., Wong, D. C., Moritsugu, Y., Dienstag, J. L., Routenberg, J. A. & Boggs, J. D. (1976). A microtiter solid phase radioimmunonssay for hepatitis A antigen and antibody. Journal of Immunology 116, 349–356.Google Scholar
Racaniello, V. R. & Baltimore, D. (1981). Cloned poliovirus complementary DNA is infectious in mammalian cells. Science 214, 916–919.CrossRefGoogle ScholarPubMed
Smith, G. L. & Moss, B. (1983). Infectious poxvirus vectors have capacity for at least 25,000 base pairs of foreign DNA. Gene 25, 135–143.CrossRefGoogle Scholar
Smith, G. L., Mackett, M. & Moss, B. (1983 a). Infectious vaccinia virus recombinants that express hepatitis B virus surface antigen. Nature 302, 490–495.CrossRefGoogle ScholarPubMed
Smith, G. L., Mackett, M. & Moss, B. (1983 b). Construction and characterization of an infectious vaccinia virus recombinant that expresses the influenza virus hemagglutinin gene and induces resistance to influenza virus infection in hamsters. Proceedings of the National Academy of Sciences (USA) 80, 7155–7159.CrossRefGoogle ScholarPubMed
Szmuness, W., Deinstag, J. L., Purcell, R. H., Stevens, C. E., Wong, D. C., Ikram, H., Barshany, S., Beasley, P. B., Desmyler, J. & Gaon, J. A. (1977). The prevalence of antibody to hepatitis A antigen in various parts of the world. American Journal of Epidemiology 106, 392–398.Google Scholar
Ticehurst, J. R., Racaniello, V. R., Baroudy, B. M., Baltimore, D., Purcell, R. H. & Feinstone, S. M. (1983). Molecular cloning and characterization of hepatitis A virus cDNA. Proceedings of the National Academy of Sciences (USA) 80, £5885–5889.CrossRefGoogle ScholarPubMed
Von der Helm, K. & Deinhardt, F. (1984). Cloning of hepatitis A virus genome. In Advances in Hepatitis Research (ed. Chisari, P.), pp. 263–267. New York: Masson.Google Scholar
Wong, D. C., Purcell, R. H. & Rosen, L. (1979). Prevalence of antibody to hepatitis A and hepatitis B viruses in selected populations of the South Pacific. American Journal of Epidemiology 110, 227–236.CrossRefGoogle ScholarPubMed