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The titration of toxoplasma-antibody*

Published online by Cambridge University Press:  15 May 2009

A. A. van Soestbergen
A. A. van Soestbergen
Affiliation:
Laboratory for Parasitology, Netherlands State University; Parasitology Department of the Institute for Tropical Medicine, Leyden*
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In toxoplasma-antibody titrations with the dye-test the tolerances of the parasite Toxoplasma gondii are approximately normally distributed on the logarithm of the serum dilution. Log LD 50 (the logarithm of the titre), the variance of the tolerance distribution and the variances of the sample distributions were estimated by probit analysis of data obtained with titrations of a serum which contained the antibody. An empirical expression was derived relating the fraction of parasites attacked by the antibody to the time of incubation with the antibody. Approximately the same values for the titre and the variance of the distribution were obtained for every incubation period between 20 min. and 4 hr.

The author is indebted to Mr J. C. A. Zaat and to Dr E. F. Drion of the Statistical Division of the Central Organization TNO for helpful discussions and assistance with the statistical calculations. The technical assistance of Miss A. K. Fast is gratefully acknowledged.

Type
Research Article
Information
Journal of Hygiene , Volume 60 , Issue 3 , September 1962 , pp. 333 - 339
Copyright
Copyright © Cambridge University Press 1962

References

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