Hostname: page-component-586b7cd67f-dlnhk Total loading time: 0 Render date: 2024-11-27T13:51:46.412Z Has data issue: false hasContentIssue false

The Stonehouse survey: nasopharyngeal carriage of meningococci and Neisseria lactamica

Published online by Cambridge University Press:  19 October 2009

K. A. V. Cartwright
Affiliation:
Public Health Laboratory, Great Western Road, Gloucester GL1 3NN
J. M. Stuart
Affiliation:
Department of Community Medicine, Rikenel, Gloucester GL1 1LY
D. M. Jones
Affiliation:
Public Health Laboratory, Withington Hospital, Manchester M20 8LR
N. D. Noah
Affiliation:
PHLS Communicable Disease Surveillance Centre, Colindale, London NW9 5EQ
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

A total of 6234 nasopharyngeal swabs was collected during a survey of the population of Stonehouse, Gloucestershire in November 1986 as part of an investigation into an outbreak of meningococcal disease. The overall meningococcal carriage rate was 10·9%. The carriage rate rose with age from 2·1% in the 0- to 4-year-olds to a peak of 24·5% in the 15- to 19-year-olds, and thereafter declined steadily with age. Male carriers outnumbered female carriers of meningococci by 3:2. Group B (or non-groupable) type 15 sulphonamide-resistant strains which had caused the outbreak were isolated from 1·4% of subjects. The age distribution of carriers of these strains was similar to that of other meningococci apart from an additional peak in the 5–9-year age group and a more rapid decline in carriage with increasing age. Variations in the carriage rates of the outbreak strain were seen in children attending different schools and in the residents of different areas of the town. The low carriage rate of these strains in a community during a prolonged outbreak supports the hypothesis that these organisms are less transmissible but more virulent than other strains of pathogenic meningococci.

Carriage of Neisseria lactamica, which is thought to be important in the development of meningococcal immunity, was most frequent in children under the age of 5 years and was six times commoner in this age group than carriage of Neisseria meningitidis. In older children and adults female carriers of N. lactamica increasingly outnumbered males in contrast to the male preponderance observed with meningococcal carriage.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1987

References

REFERENCES

Abbott, J. D., Jones, D. M., Painter, M. J. & Young, S. E. J. (1985). The epidemiology of meningococcal infections in England and Wales 1912–1983. Journal of Infection 11, 241257.CrossRefGoogle ScholarPubMed
Cann, K. J., Rogers, T. R., Jones, D. M., Noah, N. D. & Burns, C. (1987). Neisseria meningitidis in a primary school. Archives of Disease in Childhood. In press.CrossRefGoogle Scholar
Cartwright, K. A. V., Stuart, J. M. & Noah, N. D. (1986). An outbreak of meningococcal disease in Gloucestershire. Lancet ii, 558561.CrossRefGoogle Scholar
Fallon, R. J., Brown, W. M. & Lore, W. (1984). Meningococcal infections in Scotland 1972–82. Journal of Hygiene 93, 167180.CrossRefGoogle ScholarPubMed
Gold, R., Goldschneider, I., Lepow, M. L., Draper, T. F. & Randolph, M. (1978). Carriage of Neisseria meningitidis and Neisseria lactamica in infants and children. The Journal of Infectious Diseases 137, 112121.CrossRefGoogle ScholarPubMed
Greenwood, B. M. (1984). Meningococcal Infection. In Oxford Textbook of Medicine (ed. Ledingham, Weatherall & Warrell, ). 5. 165174.Google Scholar
Kaiser, A. B., Hennekens, C. H., Saslaw, M. S., Hayes, P. S. & Bennett, J. V. (1974). Seroepidemiology and chemoprophylaxis of disease due to sulphonamide resistant Neisseria meningitidis in a civilian population. The Journal of Infectious Diseases 130, 217224.CrossRefGoogle Scholar
Poolman, J. T., Lind, I., Jonsdottir, K., Froholm, L. O., Jones, D. M. & Zanen, H. C. (1986). Meningococcal serotypes and serogroup B disease in north-west Europe. Lancet ii, 555557.CrossRefGoogle Scholar
Stuart, J. M., Cartwright, K. A. V., Jones, D. M., Noah, N. D., Wall, R. J., Blackwell, C. C., Jephcott, A. E. & Ferguson, I. R. (1987). An outbreak of meningococcal disease in Stonehouse: planning and execution of a large scale survey. Epidemiology and Infection 99, 579589.CrossRefGoogle ScholarPubMed