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Social and geographical risk factors in Helicobacter pylori infection

Published online by Cambridge University Press:  15 May 2009

C. J. Whitaker ,
A. J. Dubiel  and
O. P. Galpin
C. J. Whitaker
Affiliation:
Centre for Applied Statistics, School of Mathematics, University College of North Wales, Dean Street, Bangor, Gwynedd, N. Wales LL57 1UT
A. J. Dubiel
Affiliation:
Centre for Applied Statistics, School of Mathematics, University College of North Wales, Dean Street, Bangor, Gwynedd, N. Wales LL57 1UT
O. P. Galpin
Affiliation:
Centre for Applied Statistics, School of Mathematics, University College of North Wales, Dean Street, Bangor, Gwynedd, N. Wales LL57 1UT
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Summary

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A correlation between childhood crowding and the later development of gastric cancer has been demonstrated by Barker and colleagues, who proposed that the relationship was the consequence of infection by an organism such as Helicobacter pylori. In order to test this hypothesis the presence of IgG antibodies to H. pylori in sera from blood donors in North Wales has been investigated. During donation sessions, donors answered questions relating to social conditions and domicile in childhood (at age 10 years) and adult life (the preceding 2 years).

A stepwise logistic regression analysis of the data demonstrated significant independent relationships between seropositivity and the following factors: sharing a bed in childhood, housing density, locality of birth, adult social class and age.

Type
Research Article
Information
Epidemiology & Infection , Volume 111 , Issue 1 , August 1993 , pp. 63 - 70
Copyright
Copyright © Cambridge University Press 1993

References

1.Warren, JR, Marshall, B. Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet 1983; i: 1273–5.Google Scholar
2.Marshall, BJ. Practical diagnosis of Helicobacter pylori. In: Helicobacter pylori in pepticulceration and gastritis, Marshall, BJ, Callum, RW, Guerrant, RL, eds. Boston: Blackwell, 1991: 139–59.Google Scholar
3.Thomsen, LL, Gavin, JB, Tasman-Jones, C. Relation of Helicobacter pylori to the human gastric mucosa in chronic gastritis of the antrum. Gut 1990; 31: 1230–6.CrossRefGoogle Scholar
4.Blaser, MJ. Gastric campylobacter-like organisms; gastritis and peptic ulcer disease. Gastroenterology 1987; 93: 371–83.CrossRefGoogle ScholarPubMed
5.Klein, PE, Graham, DY, Gaillour, A, Opekun, AR, O'sBrian, Smith E. Water source as risk factor for Helicobacter pylori infection in Peruvian children. Lancet 1991; 337: 1503–5.CrossRefGoogle ScholarPubMed
6.Sitas, F, Forman, D, Yarnell, JWG, et al. Helicobacter pylori infection rates in relation to age and social class in a population of Welshmen. Gut 1991; 32: 25–8.CrossRefGoogle Scholar
7.Dwyer, B, Kaldor, J, Tee, W, Raios, K. The prevalence of Campylobacter pylori in human populations. In: Campylobacter pylori and gastro-duodenal disease, Rathbone, BJ, & Heatley, RV, eds. Oxford: Blackwell, 1989: 190–6.Google Scholar
8.Megraud, F, Brassens-Rabbe, M, Denis, F, Belbouri, A, Hoa, DQ, Seroepidemiology of Campylobacter pylori infection in various populations. J Clin Microbiol 1989; 27: 1870–3.CrossRefGoogle ScholarPubMed
9.Crabtree, JE, Taylor, JD, Wyatt, JI, et al. Mucosal IgA recognition of Helicobacter pylori 120K Da protein, peptic ulceration and gastric pathology. Lancet 1991; 338: 332–5.CrossRefGoogle Scholar
10.Correa, P, Ruiz, B. Campylobacter pylori and gastric cancer. In: Campylobacter pylori and gastro-duodenal disease, Rathbone, BJ, Heatley, RV, eds; Oxford: Blackwell, 1989; 139–45.Google Scholar
11.Ormand, JE, Talley, NJ. Helicobacter pylori: controversies and an approach to management. Mayo Clin Proc 1990; 65: 414–26.CrossRefGoogle Scholar
12.Parsonnet, J, Friedman, GD, Vandersteen, DP, et al. Helicobacter pylori infection and the risk of gastric carcinoma, N Eng J Med 1991; 325: 1127–31.CrossRefGoogle ScholarPubMed
13.Buck, GE. Campylobacter pylori and gastroduodenal disease. Clin Microbiol Rev. 1990; 3: 1–12.CrossRefGoogle ScholarPubMed
14. OPCS Office of Population Censuses and Surveys. Mortality by occupation and social class 1951, 1971. London: HMSO, 1982.Google Scholar
15.Barker, DJP, Coggon, D, Osmond, C, Wickham, C. Poor housing in childhood and high rates of stomach cancer in England and Wales, Br J Cancer 1990; 61: 575–8.CrossRefGoogle ScholarPubMed
16.Coggon, D, Osmond, C, Barker, DJP. Stomach cancer and migration within England and Wales. Br J Cancer 1990; 61: 573–4.CrossRefGoogle ScholarPubMed
17.Galpin, OP, Whitaker, CJ, Whitaker, R, Kassab, JY. Gastric cancer in Gwynedd. Possible links with bracken. Br J Cancer 1990; 61: 737–40.CrossRefGoogle ScholarPubMed
18.Bolton, FJ, Hutchinson, DN. Evaluation of three Campylobacter pylori antigen preparations for screening sera from patients undergoing endoscopy. J Clin Pathol 1989; 42: 723–6.CrossRefGoogle ScholarPubMed
19.Payne, RW, Lane, PW, Ainsley, AE, et al. GENSTAT 5: Reference manual, Oxford: Clarendon, 1987.Google Scholar
20.Jones, DM, Eldridge, J, Fox, AJ, Sethi, P, Whorwell, PJ. Antibody to the gastric campylobacter-like organism (Campylobacter pyloridis) - clinical correlations and distribution in the normal population. J Med Microbiol 1986; 22: 57–62.CrossRefGoogle Scholar
21.Mendall, MA, Goggin, PM, Molineaux, N, et al. Childhood living conditions and Helicobacter pylori seropositivity in adult life, Lancet 1992; 339: 896–7.CrossRefGoogle ScholarPubMed
22.Parsonnet, J, Blaser, MJ, Perez-Perez, GI, Hargrett-Bean, N, Tauxe, RV. Symptoms and risk factors of Helicobacter pylori infection in a cohort of epidemiologists. Gastroenterology 1992; 102: 41–6.CrossRefGoogle Scholar
23.Nomura, A, Stemmerman, GN, Chyou, PH, Kato, I, Perez-Perez, GJ, Blaser, MJ. Helicobacter pylori infection and gastric carcinoma among Japanese Americans in Hawaii. N Engl J Med 1991; 325: 1132–6.CrossRefGoogle ScholarPubMed
24.Thomas, JE, Gibson, GR, Darboe, MK, Dale, A, Weaver, LT. Isolation of Helicobacter pylori from human faeces. Lancet 1992; 340: 1194–5.CrossRefGoogle ScholarPubMed