Hostname: page-component-745bb68f8f-v2bm5 Total loading time: 0 Render date: 2025-01-26T01:40:44.952Z Has data issue: false hasContentIssue false
  • English
  • Français

Serum antibody to poliovirus in patients in a mental deficiency hospital, with particular reference to Down's syndrome

Published online by Cambridge University Press:  15 May 2009

Eric McKay ,
Gordon Hems ,
Alexander Massie ,
Margaret A. J. Moffat  and
Kathleen McL. Phillips
Eric McKay
Affiliation:
Raeden Centre, Midstocket Road, Aberdeen
Gordon Hems
Affiliation:
Departments of Community Medicine and Statistics, University of Aberdeen
Alexander Massie
Affiliation:
Diagnostic Virus Laboratory, Department of Bacteriology, University of Aberdeen
Margaret A. J. Moffat
Affiliation:
Diagnostic Virus Laboratory, Department of Bacteriology, University of Aberdeen
Kathleen McL. Phillips
Affiliation:
Department of Child Health, University of Aberdeen
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Neutralization tests for poliovirus antibodies were carried out on 74 patients in an adult mental deficiency hospital: 37 patients with Down's syndrome and 37 non- Down's mental defectives. The distribution of antibody titres to poliovirus types 1, 2 and 3 did not differ significantly between the two groups. Most patients had antibody to at least one poliovirus typebut less than a third had antibodies at a titre of 1/8 or greater to all three types. The low level of poliovirus immunity in this population may be of epidemiological importance.

Type
Research Article
Information
Journal of Hygiene , Volume 81 , Issue 1 , August 1978 , pp. 25 - 30
Copyright
Copyright © Cambridge University Press 1978

References

REFERENCES

Adinolfi, M., Gardner, Brighitte & Martin, Wendy (1967). Observations on the levels of γG, γA and γM globulins, anti-A and anti-B agglutinins, and antibodies to Escherichia coli in Down's anomaly. Journal of Clinical Pathology 20, 860.CrossRefGoogle ScholarPubMed
Bell, , Eleanor, J. (1974). Serological surveillance of poliovirus in the West of Scotland. Communicable Diseases in Scotland 74 (iii), 16.Google Scholar
Kyriazopoulou, , Vassilki, G. & Bell, , Eleanor, J. (1972). A micrometabolic inhibition test for the estimation of poliovirus neutralizing antibodies. Bulletin of the World Health Organization 47, 171.Google ScholarPubMed
Levin, S., Nir, Erga & Mogilner, B. M. (1975). T system immune-deficiency in Down's syndrome. Pediatrics 56, 123.CrossRefGoogle ScholarPubMed
Lopez, V., Ocus, H. D., Thultne, H. C., Davis, S. D. & Wedgewood, R. J. (1975). Defective antibody response to bacteriophage øχ 174 in Down syndrome. Journal of Pediatrics 86, 207.CrossRefGoogle Scholar
Mortimer, P. P. & Cunningham, P. (1975). Sero-immunity to poliovirus in children and young women: England 1972–4. Journal of Hygiene 74, 283.CrossRefGoogle Scholar
Reid, D., Bell, , Eleanor, J., Grist, N. R. & Wilson, T. S. (1973). Poliomyelitis: a gap in immunity? Lancet ii, 899.CrossRefGoogle Scholar
Rigas, D. A., Elsasser, Patricia & Hecht, F. (1970). Impaired in vitro response of circulating lymphocytes to phytohaemagglutinin in Down's syndrome: dose- and time-response curves and relation to cellular immunity. International Archives of Allergy and Applied Immunology 39, 587.CrossRefGoogle ScholarPubMed
Sorrell, , Tania, C., Forbes, I. J., Burness, F. R. & Rischbieth, R. H. C. (1971). Depression of immunological function in patients treated with phenytoin sodium (sodium diphenylhydantoin). Lancet ii, 1233.CrossRefGoogle Scholar
Thom, Hazel & McKay, E. (1972). Gm antigenic titres in adults with Down's syndrome (Mongolism), non-mongoloid mental dofectives and healthy blood donors. Clinical and Experimental Immunology 12, 515.Google ScholarPubMed