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Seroprevalence of parvovirus B19 in urban Chilean children and young adults, 1990 and 1996

Published online by Cambridge University Press:  22 March 2002

K. ABARCA ,
B. J. COHEN  and
P. A. VIAL
K. ABARCA
Affiliation:
Centro de Investigaciones Médicas, Faculty of Medicine, Catholic University of Chile
B. J. COHEN
Affiliation:
PHLS Central Public Health Laboratory, 61, Colindale Avenue, London NW9 5HT, UK
P. A. VIAL
Affiliation:
Centro de Investigaciones Médicas, Faculty of Medicine, Catholic University of Chile
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Abstract

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An immunofluorescence test for detecting parvovirus B19 IgG was developed by infecting insect cells with recombinant baculovirus expressing the capsid protein VP1. The test was used to study the prevalence of antibodies in 725 healthy children and young adults living in Santiago, Chile. In total, 248 sera were taken in 1990 and 477 in 1996. The seroprevalence was low in children less than 5 years old (3% in 1990 and 21% in 1996). It rose during school age to a prevalence around 50%, reaching 60% in young adults. No differences were found between genders. There was a statistically significant higher seroprevalence in the low socio-economic status group in 1990 samples, but this was not observed in 1996. The higher prevalence observed in children less than 5 years of age in 1996 compared with 1990 could be explained by the occurrence of intervening epidemics of parvovirus B19 infection.

Type
Research Article
Information
Epidemiology & Infection , Volume 128 , Issue 1 , February 2002 , pp. 59 - 62
Copyright
2002 Cambridge University Press