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Serological titres to Leptospira fainei serovar hurstbridge in human sera in Australia

Published online by Cambridge University Press:  01 October 1998

R. J. CHAPPEL ,
D. A. KHALIK ,
B. ADLER ,
D. M. BULACH ,
S. FAINE ,
P. PEROLAT  and
V. VALLANCE
R. J. CHAPPEL
Affiliation:
Agriculture Victoria, Victorian Institute of Animal Science, Attwood, Victoria 3049, Australia
D. A. KHALIK
Affiliation:
Agriculture Victoria, Victorian Institute of Animal Science, Attwood, Victoria 3049, Australia
B. ADLER
Affiliation:
Department of Microbiology, Monash University, Clayton, Victoria 3168, Australia
D. M. BULACH
Affiliation:
Department of Microbiology, Monash University, Clayton, Victoria 3168, Australia
S. FAINE
Affiliation:
Department of Microbiology, Monash University, Clayton, Victoria 3168, Australia MediSci, Armadale, Victoria 3143, Australia
P. PEROLAT
Affiliation:
Institut Pasteur, Ho Chi Minh City, Vietnam
V. VALLANCE
Affiliation:
Department of Microbiology, Monash University, Clayton, Victoria 3168, Australia
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Abstract

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A set of 723 diagnostic sera from human patients, submitted for the microscopic agglutination test (MAT) for antibodies to a group of 6 leptospiral serovars, was also tested by MAT for antibodies to the recently-discovered Leptospira fainei serovar hurstbridge. MAT titres of [ges ]128 to serovar hurstbridge were detected in 13·4% of these sera, and titres of [ges ]512 in 7·2%. In contrast, none of 62 sera obtained from a control population of laboratory staff gave titres of [ges ]128. The difference between the number of titres of [ges ]128 given by the two groups of sera was highly significant (P<0·01). The titres observed may have been due to cross-reactions with other leptospiral serovars, but this could not be demonstrated. An alternative explanation is that serovar hurstbridge is present in the human population.

Type
SHORT PAPER
Information
Epidemiology & Infection , Volume 121 , Issue 2 , October 1998 , pp. 473 - 475
Copyright
© 1998 Cambridge University Press