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The seroepidemiology of Chlamydiae in Finland over the period 1971 to 1987

Published online by Cambridge University Press:  15 May 2009

Mirja Puolakkainen ,
Pentti Ukkonen  and
Pekka Saikku
Mirja Puolakkainen
Affiliation:
Department of Virology, University of Helsinki, Finland
Pentti Ukkonen
Affiliation:
Department of Virology, University of Helsinki, Finland
Pekka Saikku
Affiliation:
Department of Virology, University of Helsinki, Finland
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The seroepidemiology of chlamydial infections in the Finnish population was studied by analysing the prevalence of chlamydial complement fixing (CF) antibodies in patients sera sent for virus serological screening tests over 17 years from 1971 to 1987. The total number of sera studied was over 160 000. In the early 1970s, the prevalence of chlamydial CF antibodies (CF titres ≥8) was low (less than 2%), but later the proportion of seropositive cases rose, and in 1976, 18% of sera contained antibodies. In 1984, the seropositivity rate was over 31%. The prevalence of high chlamydial CF titres (titres ≥64) also showed annual variation. In general, under 1% of sera contained chlamydial CF antibodies in high titre, but in 1979 and 1984, distinct peaks occurred when 1·3% and 1·4% of sera, respectively, had titres ≥64 The age-related antibody positivity rate showed a decline during early infancy, an increase in childhood and adolescence, and a stable level in adulthood when approximately 20% of the sera contained antibodies. The chlamydial antigen used in this survey was genus-specific, i.e. it detects antibodies against, all chlamydial species. Epidemiological data support the hypothesis that infections due to a novel chlamydial species, TWAR chlamydia, are the most likely explanation for the relatively frequent occurrence of chlamydial CF antibodies and for the variation in CF antibody prevalence.

Type
Research Article
Information
Epidemiology & Infection , Volume 102 , Issue 2 , April 1989 , pp. 287 - 295
Copyright
Copyright © Cambridge University Press 1989

References

REFERENCES

Dekking, F. (1962). Epidemiology of ornithosis and psittacosis. Archiv für die Gesamte Virusforschung 13, 316–322.CrossRefGoogle Scholar
Grayston, J.T., Kuo, C. C., Wang, S. P. & Altman, J. (1986). A new Chlamydia psittaci strain, TWAR, isolated in acute respiratory tract infections. New England Journal of Medicine 315, 161–168.CrossRefGoogle ScholarPubMed
Grayston, J. T., Wang, S. P., Foy, H. M. & Kuo, C. C. (1982). Seroepidemiology of Chlamydia trachomatis infection. In Chiamydial Infections (ed. Mårdh, P. A., Holmes, K. K.Oriel, J. D.Piot, P. and Schachter, J.), pp. 405–419. Amsterdam: Elsevier Biomedical Press.Google Scholar
Grayston, J. T., Wang, S. P., Kuo, C. C., Mordhorst, C. H., Saikku, P. & Marrie, J. T. (1984). Seroepidemiology with TWAR, a new group of Chlamydia psittaci. Abstracts of the 24th Interscience Congress on Antimicrobial Agents and Chemotherapy. Washington. D.C.Google Scholar
Jansson, E. (1960). Ornithosis in Helsinki and some other localities in Finland. A serological and clinical study. Annales Medicinae Experimentalis et Biologiae Fenniae 38 Suppl. 4yes, 1–110.Google Scholar
Kleemola, M., Saikku, P., Visakorpi, R., Wang, S. P. & Grayston, J. T. (1988). Epidemics of pneumonia caused by TWAR, a new Chlamydia organism, in military trainees in Finland. Journal of Infectious Diseases 157, 230–236.CrossRefGoogle ScholarPubMed
Marrie, T. J., Grayston, J. T., Wang, S. P. & Kuo, C. C. (1987). Pneumonia associated with the TWAR strain of Chlamydia. Annals of Internal Medicine 106, 507–511.Google Scholar
Matthiesen, M. & Volkert, M. (1956). Serological diagnosis of ornithosis. A serological follow- up of 163 patients. Danish Medical Bulletin 3, 245–247.Google ScholarPubMed
Mordhorst, C. H., Wang, S. P. & Grayston, J. T. (1986). Epidemic ‘ornithosis’ and TWAR infection, Denmark 1976–1985. In Chlamydial Infections (ed. Oriel, D.Ridgway, G.Schachter, J.Taylor-Robinson, D. and Ward, M.), pp. 325–328. Cambridge: Cambridge University Press.Google Scholar
Pascienzy, T. & Sommerville, R. G. (1966). Outbreak of non-specific urethritis associated with the presence of complement-fixing antibodies to LB4 strain of TRIC agent. British Journal of Venereal Diseases 42, 191–194.Google Scholar
Pönkä, A. & Ukkonen, P. (1983). Age-related prevalence of complement-fixing antibody to Mycoplasma pneumoniae during an 8-year period. Journal of Clinical Microbiology 17, 571–575.CrossRefGoogle ScholarPubMed
Reeve, R. A. V., Carter, L. A. & Taylor, N. (1988). Respiratory tract infections and importation of exotic birds. Lancet 1, 829–830.CrossRefGoogle Scholar
Saikku, P. (1987). Lintukeuhkokuume — linnuista vai ihmisista? [Ornithosis — do we get the disease from birds or from other people?] Lintumies 21, 227–229.Google Scholar
Saikku, P., Wang, S. P., Kleemola, M., Brander, E., Rusanen, E. & Grayston, J. T. (1985).An epidemic of mild pneumonia due to an unusual Chlamydia psittaci strain. Journal of Infectious Diseases 151, 832–839.CrossRefGoogle Scholar
Schacter, J., Cles, L., Ray, R. & Hines, P. A. (1979). Failure of serology in diagnosing chlamydial infections of the female genital tract. Journal of Clinical Microbiology 10,647–649.CrossRefGoogle Scholar
Storz, J. (1971). Chlamydia and Chlamydia-induced Diseases. Springfield, Illinois: C. C. Thomas.Google Scholar
Ukkonen, P., Hovi, T., Von Bonsdorff, C. H., Saikku, P. & Penttinen, K. (1984). Age-specific prevalence of complement-fixing antibodies to sixteen viral antigens: a computer analysis of 58500 patients covering a period of eight years. Journal of Medical Virology 13,131–148.CrossRefGoogle Scholar
Vannas, C. (1970). Ophthalmology in Finland. American Journal of Ophthalmology 70,422–426.Google Scholar
Wang, S. P. & Grayston, J. T. (1970). Immunology relationship between genital TRIC, lymphogranuloma venereum, and related organisms in a new microtiter indirect immunofluorescence test. American Journal of Ophthalmology 70, 367–374.CrossRefGoogle Scholar
Wang, S. P. & Grayston, J. T. (1982). Microimmunofluorescence antibody responses in Chlamydia trachomatis infections, a review. In Chlamydial Infections (ed. Mårdh, P. A., Holmes, K. K., Oriel, J. D., Piot, P. and Schacter, J.), pp. 301–316. Amsterdam: Elsevier Biomedical Press.Google Scholar
Wang, S. P. & Grayston, J. T. (1986). Microimmunofluorescence serological studies with the TWAR organism. In Chlamydial Infections (ed. Oriel, D., Ridgway, G., Schachter, J., Taylor-Robinson, D. and Ward, M.). pp. 329–332. Cambridge: Cambridge University Press.Google Scholar
Wong, S. Y., Gray, E. S. & Buxton, D. (1985). Acute placentitis and spontaneous abortion caused by Chiamydia psittaci of sheep origin: a histological and ultrastructural study. Journal of Clinical Pathology 38. 707–711.CrossRefGoogle Scholar
Wreghitt, T. G. & Taylor, C. E. D. (1988). Incidence of respiratory tract chlamydial infections and importation of psittance birds. Lancet 1, 582.Google Scholar