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Selective Gastrointestinal Decontamination History of recognition and measurement of colonization resistance of the digestive tract as an introduction to selective gastrointestinal decontamination

Published online by Cambridge University Press:  15 May 2009

D. van der Waaij
D. van der Waaij
Affiliation:
Laboratory for Medical Microbiology, University of Groningen, 9713 EZ Groningen, The Netherlands
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Selective decontamination of the digestive tract was developed following the observation that the digestive tract normally has considerable resistance to colonization by newly ingested bacteria. The research that eventually led to selective decontamination was performed because in the late 1960s and early 1970s, the need for prophylaxis against Gram-negative infections in immuno-compromized patients became evident. At that time, the relatively small number of antibiotics available for therapy of serious infections often lead to treatment failure. To introduce the subject of selective decontamination, this paper, therefore, starts with a short historical overview of the kind of infectious agents as well as the antibiotics available in the 1960s; particularly regarding the type and treatment of infections in severely compromised patients. The fact that the possibilities in infectious diseases were limited was the reason for our experimental search for ways of successful prophylactic treatment with minimal risk of development of resistance.

Type
Special Feature
Information
Epidemiology & Infection , Volume 109 , Issue 3 , December 1992 , pp. 315 - 326
Copyright
Copyright © Cambridge University Press 1992

References

REFERENCES

1.Smith, DT. The disturbance of the normal bacterial ecology by the administration of antibiotics with the development of new clinical syndromes. Ann Intern Med 1952; 37: 1135–43.Google Scholar
2.Julianelle, LA, Siegel, M. The epidemiology of acute respiratory infections conditioned by sulfonamides. II. Gross alterations in the nasopharyngeal flora associated with treatment. Ann Intern Med 1945; 22: 11–20.Google Scholar
3.Weinstein, L. The spontaneous occurrence of new bacterial infections during the course of treatment with streptomycin or penicillin. Am J Med Sci 1947; 214: 56–63.Google Scholar
4.Rogers, DE. The changing pattern of life-threatening microbial disease. N Engl J Med 1959; 261: 677–83.Google Scholar
5.Kessner, DM, Lepper, MH. Epidemiologic studies of Gram-negative bacilli in the hospital and community. Am J Epidemiol 1967; 85: 45–60.Google Scholar
6.Louria, DB, Kaminski, T. The effects of four antimicrobial drug regimens on sputum superinfection in hospitalized patients. Ann Rev Resp Dis 1962; 85: 649–65.Google Scholar
7.Louria, DB, Brayton, RC. The efficacy of penicillin regimens. JAMA 1963; 186: 987–90.Google Scholar
8.Rose, HD, Schreier, J. The effect of hospitalization and antibiotic therapy on the Gram-negative fecal flora. Am J Med Sci 1968; 255: 228–36.Google Scholar
9.Sherwood, LM, Parris, EE, Feingold, DS. Seminars in medicine of the Beth Israel hospital in Boston. N Engl J Med 1970; 283: 1384–91.Google Scholar
10.Vosti, KL, Goldberg, LM, Monto, AS, Rantz, LA. Host-parasite interaction in patients with infection due to Escherichia coli. The serotyping of intestinal and extra-intestinal sources. J Clin Invest 1964; 43: 2377–85.Google Scholar
11.Seldon, R, Lee, S, Wang, WLL, Bennet, JV, Eickhoff, TC. Nosocomial klebsiella infections: intestinal colonization as a reservoir. Ann Int Med 1971; 74: 657–64.Google Scholar
12.Chow, AW, Taylor, PR, Yoshikawa, TT, Guze, LB.A nosocomial outbreak of infections due to multiply resistant Proteus mirabilis: role of intestinal colonization as a major reservoir. J Infect Dis 1979; 139: 521–7.Google Scholar
13.Bernstein, CA, McDermott, W. Increased transmissibility of staphylococci to patients receiving an antimicrobial drug. N Engl J Med 1960; 262: 637–42.Google Scholar
14.Myerowitz, RL, Medeiros, AA, O'brien, TF. Recent experience with bacillemia due to Gram-negative organisms. J Infect Dis 1971; 124: 239–46.Google Scholar
15.Van der Waaij, D. The ecology of the human intestine and its consequences for overgrowth by pathogens such as Clostridium difficile. Ann Rev Microbiol 1989; 43: 69–87.Google Scholar
16.Van der Waaij, D, Tieleman-Speltie, TM, De Roeck-Hoeben, AMJ. Relation between the faecal concentration of various potentially pathogenic microorganisms and infections in individuals (mice) with severely decreased resistance to infection. Antonie van Leeuwenhoek 1978; 44: 395–405.Google Scholar
17.Poth, EJ. Critical analysis of intestinal antisepsis. JAMA 1957; 104: 1317–22.Google Scholar
18.Wilson, BR. Survival studies of whole body irradiated germfree (axenic) mice. Radiat Res 1963; 20: 477–83.Google Scholar
19.McLaughlin, MM. Dacquisto, MP, Jacobus, DP. Horowitz, RE. Effects of the germfree state on response of mice to whole body irradiation. Radiat Res 1964; 23: 333–49.Google Scholar
20.Van der Waaij, D, Sturm, CA. Antibiotic decontamination of the digestive tract of mice. Technical procedures. Lab Anim Care 1971; 69: 1–10.Google Scholar
21.Van der Waaij, D, Berghuis-de Vries, JM, Lekkerkerk-van der Wees, JEC. Colonization resistance of the digestive tract in conventional and antibiotic treated mice. J Hvg 1971: 69: 106–11.Google Scholar
22.Van der Waaij, D. Berghuis, JM. Determination of the colonization resistance of the digestive tract of individual mice. Hyg 1974; 72: 379–87.Google Scholar
23.Van der Waaij, D. Vossen, JM, Korthals, C. Altes. Hartgrink, C. Reconventionalization following antibiotic decontamination in man and animals. Amer J Clin 1977; 30: 1887–95.Google Scholar
24.Van der Waaij, D. The persistent absence of Enterobacteriaceae from the intestinal flora of mice following antibiotic treatment. J Infect Dis 1968; 118: 32–8.Google Scholar
25.Koopman, JP, Janssen, FGJ, Druten, JAM. The relation between the intestinal microflora and intestinal parameters in mice. Versuchstierk 1977; 19: 54–61.Google Scholar
26.Van der Waaij, D, Berghuis-de Vries, JM, Lekkerkerk-van der Wees, JES. Colonization resistance of the digestive tract and spread of bacteria to the lymphatic organs in mice. J Hyg 1972; 70: 335–42.Google Scholar
27.Van der Waaij, D, Berghuis, JM, Lekkerkerk, JEC. Colonization resistance of the digestive tract of mice during systemic antibiotic treatment. J. Hyg 1972; 70: 605–10.Google Scholar
28.Berg, RD, Carlington, AW. Bacterial translocation of certain indigenous bacteria from the gastrointestinal tract to mesenteric lymph nodes and other organs in a gnotobiotic mouse model. Infect Immun 1979; 23: 403–11.Google Scholar
29.Tancrede, CH, Andremont, AO. Bacterial translocation and Gram negative bacteremia in patients with hematological malignancies. J Infect Dis 1985; 152: 99–103.Google Scholar
30.Van der Waaij, D, Berghuis-de Vries, JM. Selective elimination of Enterobacteriaceae species from the digestive tract in mice and monkeys. J Hyg 1974; 72: 205–11.Google Scholar
31.Veringa, EM, Van der Waaij, D. Biological inactivation by faeces of antimicrobial drugs applicable in selective decontamination of the digestive tract. J Antimicrob Chemother 1983; 14: 605–12.Google Scholar
32.Hazenberg, MP, Van de Boom, M, Bakker, M, Van de Merwe, JP. Binding to faeces and influence on human anaerobes of antimicrobial agents used for selective decontamination. Antonie van Leeuwenhoek 1983; 50: 745–61.Google Scholar
33.Boorop-Bouma, AC, Waaij, D. Van DerTrimethoprim used for selective decontamination of the digestive tract in cts: possible route of excretion. Scand J Infect Dis 1987; 19: 361–.Google Scholar
34.Thijm, HA, Van der Waaij, D. The effect of three frequently applied antibiotics on the colonization resistance of the digestive tract of mice. J Hyg 1979; 82: 397–405.Google Scholar
35.Emmelot, CH, Van der Waaij, D. The dose at which neomycin and polymyxin B can be applied for selective decontamination the digestive tract in mice. J Hyg 1980; 84: 331–40.Google Scholar
36.Van der Waaij, D, Aberson, J, Thijm, HA, Welling, GW. The screening of four aminoglycosides in the selective decontamination of the digestive tract in mice. Infection 1982; 10: 35–40.Google Scholar
37.Wiegersma, N, Jansen, G, Van der Waaij, D. Effect of twelve antimicrobial drugs on the colonization resistance of the digestive tract of mice and on endogenous potentially pathogenic bacteria. J Hyg 1982; 88: 221–30.Google Scholar
38.Van der Waaij, D. Selective decontamination of the digestive tract with oral aztreonam and temocillin. Rev Inf Dis 1985; 7S4: S628–34.Google Scholar
39.Heidt, PJ. Selective decontamination of the digestive tract in various animal species. In: New criteria for antimicrobial therapy: maintenance of digestive tract colonization resistance. Van der Waaij, D, Verhoef, J, eds. Amsterdam, Oxford: Excerpta Modice; 1979: 54–60.Google Scholar
40.Waaij, D. Van der. Effect of antibiotics on colonization resistance. In: Medical microbiology 4. Jeljaszewicz, J, Easmon, CSF, eds. London: Academic Press 1984; 227–37.Google Scholar
41.Sleijfer, DT, Mulder, NH, De Vries-Hospers, HG, et al. Infection prevention in granulocytopenic patients by selective decontamination of the digestive tract. Eur J Cancer 1980; 16: 859–61.Google Scholar
42.De Vries-Hospers, HG, Sleijfer, DT, Mulder, NH, Van der Waaij, D, Nieweg, HO, Van Saene, HKF. Bacteriological aspects of selective decontamination of the digestive tract as a method of infection prevention in granulocytopenic patients. Antimicrob Agents Chemother 1981; 18: 812–20.Google Scholar
43.Brun-Buisson, CH, Legrans, P, Rauss, A, et al. Intestinal decontamination for control of nosocomial multiresistant Gran-negative bacilli. Ann Intern Med 1989; 110: 873–81.Google Scholar
44.Dekker, AW, Rozenberg-Arska, M, Sixma, JC, Verhoef, J. Prevention of infection by trimethoprim sulfamethoxazole plus amphotericin B in patients with acute non-lymphocytic leukaemia. N Engl J Med 1981; 95: 555–9.Google Scholar
45.Rozenberg, Arska M, Dekker, AW, Verhoel, J. Colistin and trimthoprim sulfamethoxazole for the prevention of infection in patients with acute non-lymphocytic leukaemia; decrease in emergence of resistant bacteria. Infection 1983; 11: 67–9.Google Scholar