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Second Report on the Identification of the Meningococcus in the Naso-Pharynx, with special reference to Serological Reactions1

Published online by Cambridge University Press:  15 May 2009

Fred Griffith
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The serological characters of 66 strains of meningococci obtained from the cerebro-spinal fluid in cases of meningitis have been studied. Serological tests of a similar nature have been applied to 86 strains of Gram-negative cocci, culturally identical with meningococci, obtained from the naso-pharynx of non-contacts. The two series have been compared in respect of agglutinability, agglutinogenic capacity, and absorptive capacity with the following results:

The majority of the spinal strains can be divided into two main groups by simple agglutination tests with selected spinal sera: about 27 can be assigned to Group I and 34 to Group II, the remaining five being relatively inagglutinable or equally agglutinated by sera of both groups.

Type
Research Article
Information
Journal of Hygiene , Volume 17 , Issue 2-3 , July 1918 , pp. 124 - 190
Copyright
Copyright © Cambridge University Press 1918

References

page 125 note 1 Reprinted in Journ. of Hygiene, xv. 446.Google Scholar

page 135 note 1 Later tests, however, showed that several were agglutinated by other spinal sera of Group II, M 18 and M 24. (See Table II.)

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page 189 note 1 In respect of the termination of the disease in these cases Dr Whitley kindly gave me the following information:

Of the 7 infected with Group I strains, 5 died and 1 recovered; in 1 the disease has become chronic and the result is yet in doubt.

Of the 3 infected with Group II strains 1 died and 2 recovered; strains with identical serological characters produced in one case a mild disease and in another a fulminating type.