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The role of season in the epidemiology of influenza

Published online by Cambridge University Press:  25 March 2010

R. E. Hope-Simpson
R. E. Hope-Simpson
Affiliation:
Epidemiological Research Unit, 86 Dyer Street, Cirencester, Gloucestershire
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Summary

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Four types of observations have been used to illustrate the seasonal characteristics of epidemic influenza: (1) The experience of a small population during 28 consecutive years, 1946–74, (2) world influenza outbreaks 1964–75 reported to the World Health Organization, (3) the experience of two widely separated localities at about the same latitude, 1969–74, and (4) the experience of two places at latitudes 30° + on opposite sides of the Equator, 1968–74.

The following tendencies are shown. (1) Outbreaks of influenza even in the small community came at approximately the same season almost every year. (2) Outbreaks are globally ubiquitous and epidemic loci move smoothly to and fro across the surface of the earth almost every year in a sinuous curve that runs parallel with the ‘midsummer’ curve of vertical solar radiation, but lags about six months behind it. Such findings exclude the mediation of seasonal control by any agencies of local distribution, and suggest a direct effect of variations in some component of solar radiation on virus or human host. (3) Antigenic variations in influenza A virus tended to have the same seasonal characteristics as epidemicity. This suggests that epidemicity and virus variation are two facets of one seasonally controlled process.

None of these seasonal characteristics can be explained by the current concept of influenzal epidemiology. A new hypothesis recently proposed and recapitulated in the Appendix offers a possible explanation. The primary agency mediating seasonal control remains unidentified.

Type
Research Article
Information
Journal of Hygiene , Volume 86 , Issue 1 , February 1981 , pp. 35 - 47
Copyright
Copyright © Cambridge University Press 1981

References

REFERENCES

Archetti, I. & Horsfall, F. L. (1950). Persistent antigenic variation of influenza A virus after incomplete neutralisation in ova with heterologous immune serum. Journal of Experimental Medicine 92, 441–52.CrossRefGoogle Scholar
Fothergill, J. (1784). A sketch of the epidemic disease which appeared in London towards the end of the year 1775. In The Works of John Fothergill, London (ed. Lettson, J. C.), III, pp. 251–302.Google Scholar
Gill, P. & Murphy, A. M. (1976). Naturally acquired immunity to influenza type A. A clinical and laboratory study. Medical Journal of Australia 2, 329–33.CrossRefGoogle ScholarPubMed
Hope-Simpson, R. E. (1958). The epidemiology of non-infectious diseases. a. Common upper respiratory diseases. Royal Society of Health Journal 78, 593–9.Google Scholar
Hope-Simpson, R. E. (1979). Epidemic mechanisms of type A influenza. Journal of Hygiene 83, 11–26.CrossRefGoogle ScholarPubMed
Kilbourne, E. D. (1975). The Influenza Viruses and Influenza, 508 pp. New York: Academic Press.Google Scholar
Shadrin, A. S., Marinich, E. G. & Taros, L. Y. (1977). Experimental and epidemiological estimation of seasonal and climato-geographical features of non-specific resistance of the organism to influenza. Journal of Hygiene, Epidemiology, Microbiology & Immunology 21, 156–61.Google ScholarPubMed
Strnad, P., Tumova, B., Syrucek, L., Fedova, D., Bruckova, M., Kunzowa, L., Stumpa, A., Strizova, V., Berkovicova, V. & Losova, M. (1976). Influenza and other acute respiratory diseases in the Czech Socialist Republic, 1969–74. Bulletin of the World Health Organization 54, 657–62.Google Scholar
Tromp, S. W. & Bouma, J. J. (eds) (1979). Biometeorological Survey 1979. 1A. Human Biometeorology. 1B. Animal Biometeorology. London: Heyden & Sons. (Both parts contain relevant reviews with useful references.)Google Scholar