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The response to inactivated influenza A (H3N2) vaccines: the development and effect of antibodies to the surface antigens

Published online by Cambridge University Press:  15 May 2009

A. J. Smith  and
Joan R. Davies
A. J. Smith
Affiliation:
Public Health Laboratory, St Luke's Hospital, Guildford GU1 3NT, Surrey
Joan R. Davies
Affiliation:
Public Health Laboratory, St Luke's Hospital, Guildford GU1 3NT, Surrey
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Summary

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A controlled trial of influenza vaccines in a boys' public school from November 1970 to October 1975 provided an opportunity to study the response to vaccine and the effect on subsequent natural challenge in boys with differing natural experience of influenza A strains. The response to influenza A (H3N2) vaccines was assessed by estimating homotypic and heterotypic antibodies to the surface antigens. Previous natural experience of influenza A was found to influence vaccine response and the effect of natural challenge. The antibody response to revaccination with the same strain showed a progressively poorer response to second and third doses. The protective effect of naturally acquired and vaccine-induced antibodies was assessed during two outbreaks of influenza A which occurred in the trial period.

Type
Research Article
Information
Journal of Hygiene , Volume 78 , Issue 3 , June 1977 , pp. 363 - 375
Copyright
Copyright © Cambridge University Press 1977

References

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