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Rabies vaccines and interferon

Published online by Cambridge University Press:  19 October 2009

G. S. Turner
G. S. Turner
Affiliation:
Lister Institute of Preventive Medicine, Elstree, Hertfordshire
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Summary

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Samples of Fermi, Semple, modified Semple, Duck embryo and tissue culture rabies vaccine were inoculated by different routes and in different doses into rabbits, mice and hamsters. The vaccines induced neither detectable interferon nor immediate protection against lethal challenge with CVS rabies virus.

Under similar conditions, high but transient levels of interferon were induced in control animals of the same species with the polynucleotide complex Poly I.C. Hamsters but not mice were protected by Poly I.C.-induced interferon.

No autointerference by vaccine with challenge virus was established. Vaccineinduced protection in mice was directly related to immune response.

Type
Research Article
Information
Journal of Hygiene , Volume 70 , Issue 3 , September 1972 , pp. 445 - 453
Copyright
Copyright © Cambridge University Press 1972

References

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