Hostname: page-component-78c5997874-lj6df Total loading time: 0 Render date: 2024-11-09T15:46:28.927Z Has data issue: false hasContentIssue false
  • English
  • Français

Protective efficacy of RIT 4025, a live attenuated influenza vaccine strain, and evaluation of heterotypic immunity to influenza A viruses in ferrets*

Published online by Cambridge University Press:  15 May 2009

A. Delem
A. Delem
Affiliation:
Virology Department, Recherche et Industrie Therapeutiques (RIT), 89 rue de l'Institut, B-1330 Rixensart, Belgium
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Ferrets immunized with an H3N2 recombinant of A/PR/8/34 and A/Scotland/ 840f74 (RIT 4025 vaccine strain) were almost completely protected against a challenge with the homologous strain A/Scotland/ 840/ 74. The protection was lower but highly significant when the challenge was performed with the heterologous A/Victoria/3f75 wild strain. The protection afforded by the vaccine strain was measured by three indicators: absence of temperature rise, absence or reduction of virus shedding and absence or reduction of nasal protein increase when compared with uninoculated controls.

Heterotypic immunity in this animal model was not significant when these three indicators were measured after a challenge inoculation performed 5 weeks after immunization.

Type
Research Article
Information
Journal of Hygiene , Volume 79 , Issue 2 , October 1977 , pp. 203 - 208
Copyright
Copyright © Cambridge University Press 1977

References

REFERENCES

Delem, A. (1976). Response of ferrets to infection with a live attenuated influenza virus and to subsequent heterologous challenge. Developments in Biological Standardization 33, 226.Google ScholarPubMed
Lobmann, M., Delem, A., Peetermans, J. & Huygelen, C. (1976). Laboratory characteristics of an attenuated influenza type A (H3N2) virus (‘Alice’ strain). Journal of Hygiene 77, 181–8.CrossRefGoogle ScholarPubMed
Lowry, O. H., Rosebrough, N. J., Farr, A. L. & Randall, P. J. (1951). Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry 193, 265&75.CrossRefGoogle ScholarPubMed
McLaren, C. (1973). General discussion. Developments in Biological Standardization 20, 240.Google Scholar
Mclaren, c – Potter, C. W. (1974). Immunity to influenza in ferrets. VII. Effect of previous infection with heterotypic and heterologous influenza viruses on the response of ferrets to inactivated influenza virus vaccines. Journal of Hygiene 72, 91–100.CrossRefGoogle ScholarPubMed
Potter, C. W., Oxford, J. S., Shone, S. L., McLaren, C. & Stuart-Harris, C. (1972). Immunity to influenza in ferrets. 1. Response to live and killed virus. British Journal of Experimental Pathology 53, 153–67.Google ScholarPubMed
Potter, C. W. & Jennings, R. (1976). The hamster as a model system for the study of influenza vaccines. Postgraduate Medical Journal 52, 345–51.CrossRefGoogle Scholar
Prinzie, A., Delem, A. & Huygelen, C. (1976). Protective efficacy of a live, attenuated, influenza virus vaccine (‘Alice’ strain). Postgraduate Medical Journal 52, 395–8.CrossRefGoogle ScholarPubMed
Schulman, J. L. & Kilbourne, E. D. (1965). Induction of partial specific heterotypic immunity in mice by a single infection with influenza A virus. Journal of Bacteriology 89, 170–4.CrossRefGoogle ScholarPubMed