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Prospective study of diarrhoeal disease in a cohort of rural Mexican children: incidence and isolated pathogens during the first two years of life

Published online by Cambridge University Press:  15 May 2009

Alejandro Cravioto ,
Rosa E. Reyes ,
Roberto Ortega ,
Guadalupe Fernández ,
Raymundo Hernández  and
Dolores López
Alejandro Cravioto
Affiliation:
Programme for Research in New Immunizing Agents, Instituto Nacional de Ciencias y Tecnología-DIF, Avenida Imán 1, Tlalpan 14410, D.F., México
Rosa E. Reyes
Affiliation:
Programme for Research in New Immunizing Agents, Instituto Nacional de Ciencias y Tecnología-DIF, Avenida Imán 1, Tlalpan 14410, D.F., México
Roberto Ortega
Affiliation:
Programme for Research in New Immunizing Agents, Instituto Nacional de Ciencias y Tecnología-DIF, Avenida Imán 1, Tlalpan 14410, D.F., México
Guadalupe Fernández
Affiliation:
Programme for Research in New Immunizing Agents, Instituto Nacional de Ciencias y Tecnología-DIF, Avenida Imán 1, Tlalpan 14410, D.F., México
Raymundo Hernández
Affiliation:
Programme for Research in New Immunizing Agents, Instituto Nacional de Ciencias y Tecnología-DIF, Avenida Imán 1, Tlalpan 14410, D.F., México
Dolores López
Affiliation:
Programme for Research in New Immunizing Agents, Instituto Nacional de Ciencias y Tecnología-DIF, Avenida Imán 1, Tlalpan 14410, D.F., México
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Colonization of the intestine by putative pathogens was followed longitudinally in a cohort of 56 infants born during one calendar year in a rural Mexican village with faecal cultures taken every fortnight and every time a child had diarrhoea. The frequency of isolation of pathogens during episodes of diarrhoea was compared with that of matched controls from the same cohort. Incidence of diarrhoea during the first year of life was 98%, diminishing to 93% during the second year. The incidence curves for each year were not significantly different (P > 0·1). Isolation of enteropathogenic Escherichia coli, enterotoxigenic Escherichia coli producing heat-stable (ST) and/or heat-labile (LT) enterotoxins and rotaviruses was significantly higher in infants with diarrhoea during the first 2 years of life. In the case of shigella, although no significant differences were found by semester of life, 13 of 16 children in which these strains were found had diarrhoea. Isolation of Salmonella spp., Campylobacter spp. and protozoa were not significantly different in the two groups during the period studied. Strains showing localized adherence to HEp-2 cells or the presence of colonization factor antigens I or E8775 were found with significantly higher frequency in children with diarrhoea. Eighty-two percent of ST+ or LT+ ETEC strains isolated produced one of the three known colonization factors.

Type
Special Article
Information
Epidemiology & Infection , Volume 101 , Issue 1 , August 1988 , pp. 123 - 134
Copyright
Copyright © Cambridge University Press 1988

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