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The Precipitation Reaction: Experiments on Multiple Zones

Published online by Cambridge University Press:  15 May 2009

G. L. Taylor  and
Muriel E. Adair
G. L. Taylor
Affiliation:
John Lucas Walker Students, From the Department of Pathology, University of Cambridge
Muriel E. Adair
Affiliation:
John Lucas Walker Students, From the Department of Pathology, University of Cambridge
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1. An antiserum containing antibodies for two unrelated antigens, crystalline egg albumin and crystalline horse serum albumin, has been prepared.

2. In titrations of the antiserum against mixtures of these antigens it has been possible to produce a single zone or two zones of optimal particulation by varying the relative concentrations of the components in the antigenic mixtures. It is evident, therefore, that whilst (a) a single zone does not necessarily indicate a single antigen-antibody system, (b) multiple zones suggest the presence of more than one antigen-antibody system.

Type
Research Article
Information
Journal of Hygiene , Volume 35 , Issue 2 , May 1935 , pp. 169 - 173
Copyright
Copyright © Cambridge University Press 1935

References

REFERENCES

Dean, H. R., Taylor, G. L. and Adair, Muriel E. (1935). The precipitation reaction: experiments with an antiserum containing two antibodies. J. Hygiene, 35, 69.CrossRefGoogle ScholarPubMed
Dean, H. R. and Webb, R. A. (1926). The influence of optimal proportions of antigen and antibody in the serum precipitation reaction. J. Path. and Bact. 29, 473.CrossRefGoogle Scholar
Goldsworthy, N. E. (1928). The occurrence of multiple zones in the serum precipitation reaction. Ibid. 31, 525.Google Scholar
Goldsworthy, N. E. and Rudd, G. V. (1935). Complexity of antigens in relation to zones in the precipitation reaction. Ibid. 40, 169.Google Scholar
Taylor, G. L. (1931). The results of some quantitative experiments on the serum precipitation reaction. J. Hygiene, 31, 56.CrossRefGoogle ScholarPubMed
Taylor, G. L., Adair, G. S. and Adair, Muriel E. (1932). The estimation of proteins by the precipitation reaction. Ibid. 32, 340.Google Scholar
Wells, A. Q. (1931). Variations in the antigen content of serum in disease. Lancet, 2, 1348.CrossRefGoogle Scholar