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Pharyngeal carriage of Neisseria meningitidis and Neisseria lactamica in households with infants within areas with high and low incidences of meningococcal disease

Published online by Cambridge University Press:  19 October 2009

S. F. Olsen ,
B. Djurhuus ,
K. Rasmussen ,
H. D. Joensen ,
S. O. Larsen ,
H. Zoffman  and
I. Lind
S. F. Olsen
Affiliation:
Central Hospital, Tórshavn, Faroe Islands
B. Djurhuus
Affiliation:
Central Hospital, Tórshavn, Faroe Islands
K. Rasmussen
Affiliation:
Central Hospital, Tórshavn, Faroe Islands
H. D. Joensen
Affiliation:
Chief Medical Officer, Faroe Islands
S. O. Larsen
Affiliation:
Statens Seruminstitut, Copenhagen, Denmark
H. Zoffman
Affiliation:
Statens Seruminstitut, Copenhagen, Denmark
I. Lind
Affiliation:
Statens Seruminstitut, Copenhagen, Denmark
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In a household survey in the Faroe Islands, an isolated community with hyperendemic occurrence of meningococcal disease due to serogroup B 15, 1604 persons were examined for pharyngeal carriage of Neisseria meningitidis and N. lactamica. Two areas were chosen having experienced high (HIA), and two having experienced low incidences (LIA) of disease. Living in HIA compared with LIA was associated with higher risk of N. meningitidis B 15 carriage and lower risk of N. lactamica carriage, with odds ratios of 2·7 (95% confidence interval (CI) 1·4–5·1, P = 0·003) and 0·41 (95% CI 0·31–0·53, P < 0·0001), respectively. In HIA the risk of N. meningitidis carriage was much lower in non-carriers than carriers of N. lactamica, with an odds ratio of 0·19 (95% CI 0·08–0·47, P = 0·0003); in LIA this association (odds ratio 0·51, P = 0·05) was much weaker. Children 0–14 years had substantially higher risk of being carriers of N. meningitidis group B 15 if the mothers were so, with an odds ratio of 11 (95% CI 4–29, P < 0·0001).

Type
Research Article
Information
Epidemiology & Infection , Volume 106 , Issue 3 , June 1991 , pp. 445 - 457
Copyright
Copyright © Cambridge University Press 1991

References

REFERENCES

1.Broome, CV.The carrier state: Neisseria meningitidis. J Antimicrob Chemother 1986; 18 (suppl. A): 25–34.CrossRefGoogle ScholarPubMed
2.Poolman, JT., Lind, I, Jónsdóttir, K, Frøjolm, LO, Jones, DM, Zannen, HC.Meningococcal serotypes and serogroup B disease in North-West Europe. Lancet 1986; ii: 555–7.CrossRefGoogle Scholar
3.Weihe, P, Mathiassen, B, Rasmussen, JM, Petersen, T, Isager, H.. An epidemic outbreak of group B meningococcal disease on the Faroe Islands. Scand J Infect Dis 1988; 20: 291–6.CrossRefGoogle Scholar
4.Joensen, HD. Annual Report of the Chief Medical Officer of the Faroe Islands 1989. Tórshavn, 1990. In press.Google Scholar
5.Lind, I, Joensen, HD, Poolman, JT, Zoffmann, H.Meningococcal disease in the Faroe Islands. Antonie van Leeuwenhoek J Microbiol 1986; 52: 223–4.CrossRefGoogle Scholar
6.Mantel, N, Haenszel, W.Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 1959; 22: 719–48.Google ScholarPubMed
7.Miettinen, OS.Estimability and estimation in case-referent studies. Am J Epidemiol 1976; 103: 226–35.CrossRefGoogle ScholarPubMed
8.Cartwright, KAV, Stuart, JM, Jones, DM, Noah, ND.The Stonehouse survey: nasopharyngeal carriage of meningococci and N. ladamica. Epidem Infect 1987: 99; 591–601.CrossRefGoogle Scholar
9.Gold, R, Goldscheider, I, Lepow, ML, Draper, TF, Randolf, M.Carriage of N. meningitidis and N. ladamica in infants and children. J Infect Dis 1978; 137: 112–21.CrossRefGoogle Scholar
10.Marks, MI, Frasch, CE, Shapera, RM.Meningococcal colonization and infection in children and their households. Am J Epidemiol 1979; 109: 563–71.CrossRefGoogle Scholar
11.Blakebrough, IS, Greenwood, BM, Whittle, HC, Bradly, AK, Gilles, HM.The epidemiology of infections due to N. meningitidis and N. ladamica in a Northern Nigerian community. J Infect Dis 1982; 146: 626–37.CrossRefGoogle Scholar
12.Stuart, JM, Cartwright, KA, Robinson, PM, Noah, ND.Effect of smoking on meningococcal carriage. Lancet 1989; ii: 723–5.CrossRefGoogle Scholar
13.Saez-Nieto, JA.Dominguez, JR, Monton, JL et al. Carriage of Neisseria meningitidis and Neisseria lactamica in a school population during an epidemic period in Spain. J Hyg 1985; 95: 279–88.CrossRefGoogle Scholar
14.Saez-Nieto, JA, Campos, J, Latore, C. et al. Prevalence of N. meningitidis in family members of patients with meningococcal infection. J Hyg 1982; 89: 139–48.CrossRefGoogle Scholar
15.JM, Last, ed. A dictionary of epidemiology. New York, Oxford, Toronto: Oxford University Press, 1983: 7.Google Scholar