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Pertussis agglutinins in vaccinated children: better response with adjuvant

Published online by Cambridge University Press:  15 May 2009

N. W. Preston ,
R. I. Mackay ,
F. N. Bamford ,
J. E. Crofts  and
W. L. Burland
N. W. Preston
Affiliation:
Department of Bacteriology and Virology, University of Manchester, Manchester M13 9PT
R. I. Mackay
Affiliation:
Hope Hospital, Salford, Lancs. M6 8HD
F. N. Bamford
Affiliation:
Department of Child Health (University of Manchester)St Mary's Hospital, Manchester M13 0JH
J. E. Crofts
Affiliation:
Vaccine Production Unit, Evans Biologicals Ltd, Speke, Liverpool L24 9JD
W. L. Burland
Affiliation:
Glaxo Laboratories, Greenford, Middlesex
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Summary

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Children were immunized with a single batch of pertussis vaccine, either adsorbed on aluminium hydroxide or plain. With a primary course of three injections, adsorbed vaccine produced higher titres of pertussis agglutinins in the serum than did plain vaccine. There was no obvious difference in response between those who received the three doses at intervals of 1–2 months, starting at 3–4 months of age, and those in whom the third dose was delayed until about 6 months after the second, but the number of children in each group was small.

Type
Research Article
Information
Journal of Hygiene , Volume 73 , Issue 1 , August 1974 , pp. 119 - 125
Copyright
Copyright © Cambridge University Press 1974

References

REFERENCES

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