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On the Danysz Effect with reference to the Toxin-Antitoxin Reaction

Published online by Cambridge University Press:  15 May 2009

J. A. Craw
J. A. Craw
Affiliation:
Grocers' Company Research Scholar, Hon. Demonstrator in Physiology, The London Hospital Medical College.
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1. It is inadmissible to study the “Danysz Effect” on tetanolysin owing to its rapid deterioration.

2. The so-called “equivalents” of toxin and antitoxin deduced by Arrhenius and Madsen are arbitrary.

3. No evidence has yet been advanced that the “Danysz Effect” has a limiting value when the time of contact of the first fraction of toxin with the antitoxin is prolonged.

4. If a limiting value of the “Danysz Effect” exist that calculated by Arrhenius is probably erroneous.

5. The monomolecular formula used by Arrhenius is merely an interpolation.

6. The “Danysz Effect” is much better represented by a bimolecular formula.

7. No confirmation of the “equivalents” of toxin and antitoxin has as yet been obtained from the “Effect.”

8. Expediency appears to be the only justification for assuming that the “Effect” is due to either a modified antitoxin or to a modified toxin, viz. epitoxonoid.

9. All the phenomena of the “Effect” hitherto advanced have their counterpart in the staining of paper, porcelain, etc., by anilin dyes.

Type
Research Article
Information
Journal of Hygiene , Volume 7 , Issue 4 , July 1907 , pp. 501 - 511
Copyright
Copyright © Cambridge University Press 1907

References

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