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A new, surface-antigen-adsorbed influenza virus vaccine. I. Studies on immunogenicity in hamsters

Published online by Cambridge University Press:  15 May 2009

R. Jennings ,
C. W. Potter ,
C. McLaren  and
Margaret Brady
R. Jennings
Affiliation:
Academic Division of Pathology (Virology), University of Sheffield Medical School, Beech Hill Road, Sheffield S10 2RX
C. W. Potter
Affiliation:
Academic Division of Pathology (Virology), University of Sheffield Medical School, Beech Hill Road, Sheffield S10 2RX
C. McLaren
Affiliation:
Academic Division of Pathology (Virology), University of Sheffield Medical School, Beech Hill Road, Sheffield S10 2RX
Margaret Brady
Affiliation:
Evans Biologicals Ltd, Speke, Liverpool L24 9JD
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The ability of a new, surface-antigen-adsorbed influenza virus vaccine to induce serum antibody in hamsters, and to protect these hamsters against subsequent homologous virus challenge, is reported. In addition, similar studies in hamsters have also been carried out using the surface antigen material prior to adsorption to the aluminium hydroxide carrier. The new, adsorbed vaccine is at least as effective as inactivated saline influenza virus vaccine in inducing serum antibody and protection in hamsters; the unadsorbed surface antigen material, however, did not confer protection to hamsters challenged subsequently with homologous virus.

Type
Research Article
Information
Journal of Hygiene , Volume 75 , Issue 3 , December 1975 , pp. 341 - 352
Copyright
Copyright © Cambridge University Press 1975

References

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