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Neutralizing antibodies against 33 human adenoviruses in normal children in Rome

Published online by Cambridge University Press:  25 March 2010

E. D'ambrosio ,
N. Del Grosso ,
A. Chicca  and
M. Midulla
E. D'ambrosio
Affiliation:
Centro C.N.R. Virus Respiratori c/o Clinica Pediatrica, Università di Roma. Viale Regina Elena, 324. 00161 Roma, Italy.
N. Del Grosso
Affiliation:
Centro C.N.R. Virus Respiratori c/o Clinica Pediatrica, Università di Roma. Viale Regina Elena, 324. 00161 Roma, Italy.
A. Chicca
Affiliation:
Centro C.N.R. Virus Respiratori c/o Clinica Pediatrica, Università di Roma. Viale Regina Elena, 324. 00161 Roma, Italy.
M. Midulla
Affiliation:
Centro C.N.R. Virus Respiratori c/o Clinica Pediatrica, Università di Roma. Viale Regina Elena, 324. 00161 Roma, Italy.
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There are few data about the distribution of neutralizing antibodies (NA) against adenovirus types in the Italian population, especially the high-numbered ones. We tested the sera from 453 children and 51 young adults to evaluate NA against adenovirus prototypes 1–33. Using the microneutralization test, 338 (74·6%) of the children's sera were positive for at least one adenovirus type. Antibody to type 2 was the most frequently detected followed, in descending order, by antibody to types 5, 1 and 3. All these types are known to be associated with disease but antibody to type 7, a type also associated with disease, was less frequent than that to other serotypes such as 18 and 31, the pathogenicity of which in man is not clearly established. The antibody positivity rate rose with age for the more frequent types while it did not vary for the less frequent ones. The number of sera with NA against more than one adenovirus type increased with age. With regard to types 1–8, we found that their frequencies in Italy were similar to those found in the U.S.A.

Type
Research Article
Information
Journal of Hygiene , Volume 89 , Issue 1 , August 1982 , pp. 155 - 161
Copyright
Copyright © Cambridge University Press 1982

References

REFERENCES

Bell, J. A., Rowe, W. P. & Rosen, L. (1962). II. Adenoviruses American Journal of Public Health 52, 902–907.CrossRefGoogle Scholar
Brandt, C. D., Kim, H. W., Vargosko, A. J., Jeffries, B. C., Arrobio, J. O., Rindge, B., Parrott, R. H. & Chanock, R. M. (1969). Infections in 18,000 infants and children in a controlled study of respiratory tract disease. I. Adenovirus pathogenicity in relation to serologic type and illness syndrome. American Journal of Epidemiology 90, 484–500.CrossRefGoogle Scholar
Fox, J. P., Brandt, C. D., Wassermann, F. E., Hall, C. E., Spigland, I., Kogon, A. & Elveback, L. R. (1969). The virus watch program: a continuing surveillance of viral infections in metropolitan New York families. American Journal of Epidemiology 89, 25–50.CrossRefGoogle Scholar
Foy, H. M. & Grayston, J. T. (1976). Adenoviruses. In Viral Infections in Humans (ed. Evans, A. S.), New York: Wiley.Google Scholar
Jackson, G. G. & Muldoon, R. L. (1975). Viruses Causing Common Respiratory Infections in Man, p. 183. Chicago, London: University of Chicago Press.Google ScholarPubMed
Kasel, J. A. (1979). Adenoviruses. In Diagnostic Procedures for Viral, Rickettsial and Chlamydial infections, 5th ed. (ed. Lennette, E. H. and Schmidt, N. J.). Washington, D.C.: American Public Health Association.Google Scholar
Potter, C. W. & Shedden, W. I. H. (1963). The distribution of adenovirus antibodies in normal children. Journal of Hygiene 61, 155–160.CrossRefGoogle ScholarPubMed
Schmidt, N. J., Lennette, E. H. & King, C. J. (1966). Neutralizing, hemagglutination-inhibition and group complement-fixing antibody responses in human adenovirus infections. Journal of Immunology 97, 64–74.CrossRefGoogle ScholarPubMed
Sterner, G. (1962). Adenovirus infection in childhood: an epidemiological and clinical survey among Swedish children. Acta Paediatrica Scandinavica. Supplementum 142, 1–30.Google ScholarPubMed
Tai, F. H. & Grayston, J. T. (1962). Adenovirus neutralizing antibodies in persons on Taiwan. Proceedings of the Society for Experimental Biology and Medicine 109, 881–884.CrossRefGoogle ScholarPubMed
Taylor, P. E. (1977). Adenoviruses: diagnosis of infections. In Comparative Diagnosis of Viral Diseases (ed. Kurstak, E. and Kurstak, C.). New York: Academic Press.Google Scholar
Wigand, R., Gelderblom, H. & Wadell, G. (1980). New human adenovirus (candidate adenovirus 36), a novel member of subgroup D. Archives of Virology 64, 225–233.CrossRefGoogle ScholarPubMed