Hostname: page-component-745bb68f8f-grxwn Total loading time: 0 Render date: 2025-01-08T14:03:09.408Z Has data issue: false hasContentIssue false
  • English
  • Français

Neuraminidase and resistance to vaccination with live influenza A2 Hong Kong vaccines*

Published online by Cambridge University Press:  15 May 2009

A. N. Slepushkin ,
G. C. Schild ,
A. S. Beare ,
Susan Chinn  and
D. A. J. Tyrrell
A. N. Slepushkin
Affiliation:
Clinical Research Centre, Harrow, Middlesex, HA1 3UJ, Common Cold Unit, Salisbury, Wilts, and World Influenza Centre, National Institute for Medical Research, Mill Hill, London, N.W. 7
G. C. Schild
Affiliation:
Clinical Research Centre, Harrow, Middlesex, HA1 3UJ, Common Cold Unit, Salisbury, Wilts, and World Influenza Centre, National Institute for Medical Research, Mill Hill, London, N.W. 7
A. S. Beare
Affiliation:
Clinical Research Centre, Harrow, Middlesex, HA1 3UJ, Common Cold Unit, Salisbury, Wilts, and World Influenza Centre, National Institute for Medical Research, Mill Hill, London, N.W. 7
Susan Chinn
Affiliation:
Clinical Research Centre, Harrow, Middlesex, HA1 3UJ, Common Cold Unit, Salisbury, Wilts, and World Influenza Centre, National Institute for Medical Research, Mill Hill, London, N.W. 7
D. A. J. Tyrrell
Affiliation:
Clinical Research Centre, Harrow, Middlesex, HA1 3UJ, Common Cold Unit, Salisbury, Wilts, and World Influenza Centre, National Institute for Medical Research, Mill Hill, London, N.W. 7
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Thirty-seven volunteers were inoculated intranasally with living attenuated influenza A 2 viruses. Rising titres of circulating antineuraminidase (AN) were detected in 14 of 17 infected volunteers. AN was also found in nasal secretions. Statistical analysis showed that there was a correlation between the titres of haemagglutination-inhibituig antibody (HI) and AN in nasal washings, and between AN in blood and washings. Resistance to infection could be predicted from antibody titres in 29 of 37 volunteers and blood AN alone predicted the outcome of 25 volunteers.

Type
Research Article
Information
Journal of Hygiene , Volume 69 , Issue 4 , December 1971 , pp. 571 - 578
Copyright
Copyright © Cambridge University Press 1971

References

REFERENCES

Beare, A. S., Maassab, H. F., Tyrrell, D. A. J., Slepushkin, A. N. & Hall, T. S. (1971). A comparative study of attenuated influenza viruses. Bulletin of the World Health Organization. 44, 593.Google ScholarPubMed
Downie, J. C. (1970). Neuraminidase and haemagglutination-inhibiting antibodies in serum and nasal secretions of volunteers immunized with attenuated and inactivated influenza B/Eng/13/65 virus vaccines. Journal of Immunology 105, 620.CrossRefGoogle Scholar
Downie, J. C. & Stuart-Harris, C. H. (1970). The production of neutralizing activity in serum and nasal secretion following immunization with influenza B virus. Journal of Hygiene 68, 233.CrossRefGoogle ScholarPubMed
Easterday, B., Laver, W. G., Pereira, H. G. & Schild, G. C. (1969). Antigenic composition of recombinant virus strains produced from human and avian influenza A viruses. Journal of General Virology 5, 83.CrossRefGoogle ScholarPubMed
Kilbourne, E. D., Christenson, W. N. & Sande, M. (1968). Antibody response in man to influenza virus neuraminidase following influenza. Journal of Virology 2, 761.CrossRefGoogle Scholar
Kilbourne, E. D., Laver, W. G., Schulman, J. L. & Webster, R. G. (1968). Antiviral activity of antiserum specific for influenza virus neuraminidase. Journal of Virology 2, 281.CrossRefGoogle ScholarPubMed
Mann, J. J., Waldman, R. H., Togo, Y., Heiner, G. G., Dawkins, A. T. & Kasel, J. A. (1968). Antibody response to respiratory secretions of volunteers given live and dead influenza virus. Journal of Immunology 100, 726.CrossRefGoogle ScholarPubMed
Perkins, J. C., Tucker, D. N., Knopf, H. L. S., Wenzel, R. P., Hornick, R. B., Kapikian, A. Z. & Chanock, R. M. (1969). Evidence for protective effect of an inactivated rhinovirus vaccine administered by the nasal route. American Journal of Epidemiology 90, 318.CrossRefGoogle ScholarPubMed
Schild, G. C., McCahon, D. & Kendal, A. P. (1970). The Biology of Large RNA Viruses, p. 638. London: Academic Press.Google Scholar
Schild, G. C. & Newman, R. W. (1969). Antibody against influenza A2 virus neuraminidase in human sera. Journal of Hygiene 67, 353.CrossRefGoogle ScholarPubMed
Schild, G. C. & Pereira, H. G. (1969). Characteristics of the ribonucleo-protein and neuraminidase of influenza A viruses by immunodiffusion. Journal of General Virology 4, 355.CrossRefGoogle Scholar
Schild, G. C., Winters, W. D. & Brand, C. M. (1971). Serological diagnosis of human influenza infections by immunoprecipitin techniques. Bulletin of the World Health Organization. (In the Press.)Google ScholarPubMed
Smith, C. B., Purcell, K. H., Bellanti, J. A. & Chanock, R. M. (1966). Protective effect of antibody to parainfluenza type 1 virus. New England Journal of Medicine 275, 1145.CrossRefGoogle ScholarPubMed
Tremonti, B. P., Lin, T. J. L. & Jackson, G. G. (1968). Neutralizing activity in nasal secretions and serum in resistance of volunteers to parainfluenza virus type 2. Journal of Immunology 101, 572.CrossRefGoogle ScholarPubMed
Tyrrell, D. A. J. (1963). The use of volunteers. The American Review of Respiratory Diseases 88, Supplement 128.Google ScholarPubMed
Webster, R. G. & Laver, W. G. (1967). Preparation and properties of antibody directed specifically against the neuraminidase of influenza virus. Journal of Immunology 99, 49.CrossRefGoogle ScholarPubMed