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The microbiology and outcome of sepsis in Victoria, Australia

Published online by Cambridge University Press:  19 August 2005

V. SUNDARARAJAN ,
T. KORMAN ,
C. MACISAAC ,
J. J. PRESNEILL ,
J. F. CADE  and
K. VISVANATHAN
V. SUNDARARAJAN
Affiliation:
Victorian Department of Human Services, Melbourne, Victoria, Australia
T. KORMAN
Affiliation:
Department of Infectious Diseases, Monash Medical Centre, Clayton, Victoria, Australia
C. MACISAAC
Affiliation:
Intensive Care Unit, The Royal Melbourne Hospital, Parkville, Victoria, Australia
J. J. PRESNEILL
Affiliation:
Intensive Care Unit, The Royal Melbourne Hospital, Parkville, Victoria, Australia
J. F. CADE
Affiliation:
Intensive Care Unit, The Royal Melbourne Hospital, Parkville, Victoria, Australia
K. VISVANATHAN
Affiliation:
Department of Infectious Diseases, Monash Medical Centre, Clayton, Victoria, Australia Department of Medicine, The Royal Melbourne Hospital, The University of Melbourne Staph and Strep Group, Murdoch Children's Research Institute, Victoria, Australia
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Abstract

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We analysed data from 33741 patients with ICD-10-AM-defined sepsis from an Australian hospital morbidity dataset to investigate the relationships between specific types of organisms, potential risk factors for infection, organ dysfunction, ICU utilization and hospital mortality. A total of 24% of patients received some of their care in an intensive care unit, and the overall hospital mortality rate was 18%. Gram-positive bacteria were isolated in 27% of cases and Gram-negative bacteria in 20%. Sepsis due to Staphylococcus aureus was associated with vascular and joint devices whereas Pseudomonasaeruginosa and Gram-negative rods were more common with genitourinary devices and lymphoproliferative disease. Sepsis-associated organ dysfunction most commonly involved the respiratory system, followed by the renal and circulatory systems. These patterns may provide useful clues to the pathogenesis and therapy of this often fatal syndrome which is a major ongoing problem for hospitalized patients.

Type
Research Article
Information
Epidemiology & Infection , Volume 134 , Issue 2 , April 2006 , pp. 307 - 314
Copyright
2005 Cambridge University Press