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The mechanism of cross-protection afforded by dengue virus against West Nile virus in hamsters*

Published online by Cambridge University Press:  15 May 2009

Winston H. Price  and
Inderjit S. Thind
Winston H. Price
Affiliation:
Kenneth F. Maxcy Laboratories, Department of Epidemiology, School of Hygiene and Public Health, The Johns Hopkins University, Baltimore, Maryland 21205
Inderjit S. Thind
Affiliation:
Kenneth F. Maxcy Laboratories, Department of Epidemiology, School of Hygiene and Public Health, The Johns Hopkins University, Baltimore, Maryland 21205
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Summary

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The protection afforded by similar concentrations of different dengue virus serotypes against a subsequent challenge of West Nile virus was studied in hamsters. The New Guinea C strain of dengue 2 virus gave the best protection. It was found that the anamnestic neutralizing antibody response induced by the challenge West Nile virus against West Nile virus in hamsters, previously immunized with dengue 2 virus, might play a major role in the cross-protection observed in this system.

Type
Research Article
Information
Journal of Hygiene , Volume 70 , Issue 4 , December 1972 , pp. 611 - 617
Copyright
Copyright © Cambridge University Press 1972

References

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