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Low socioeconomic status and risk for infection with Human Herpesvirus 8 among HIV-1 negative, South African black cancer patients

Published online by Cambridge University Press:  16 November 2004

J. M. WOJCICKI ,
R. NEWTON ,
MI. URBAN ,
L. STEIN ,
M. HALE ,
M. PATEL ,
P. RUFF ,
R. SUR ,
D. BOURBOULIA  and
F. SITAS
J. M. WOJCICKI
Affiliation:
Center for AIDS Prevention Studies, University of California, San Francisco, USA
R. NEWTON
Affiliation:
Cancer Epidemiology Unit, The Radcliffe Infirmary, Oxford University, UK
MI. URBAN
Affiliation:
The South African Cancer Epidemiology Research Group, Johannesburg, South Africa
L. STEIN
Affiliation:
The South African Cancer Epidemiology Research Group, Johannesburg, South Africa
M. HALE
Affiliation:
Department of Anatomical Pathology, the National Health Laboratory Service and the University of the Witwatersrand, South Africa
M. PATEL
Affiliation:
Division of Medical Oncology, Department of Medicine, Faculty of Health Sciences, University of Witwatersrand, South Africa The Haematology/Oncology Division, Department of Medicine at Chris Hani Baragwanath Hospital, South Africa
P. RUFF
Affiliation:
Division of Medical Oncology, Department of Medicine, Faculty of Health Sciences, University of Witwatersrand, South Africa Department of Radiation Oncology, McMaster University Hamilton Regional Cancer Centre, Hamilton, Ontario, Canada
R. SUR
Affiliation:
Division of Medical Oncology, Department of Medicine, Faculty of Health Sciences, University of Witwatersrand, South Africa Johannesburg Hospital, Johannesburg, South Africa
D. BOURBOULIA
Affiliation:
Cancer Research UK, Viral Oncology Group, Wolfson Institute for Biomedical Research, University College London, UK
F. SITAS
Affiliation:
The South African Cancer Epidemiology Research Group, Johannesburg, South Africa The New South Wales Cancer Council, Woolloomooloo, Australia
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Abstract

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Between January 1994 and October 1997, we interviewed 2576 black in-patients with newly diagnosed cancer in Johannesburg and Soweto, South Africa. Blood was tested for HIV-1 and HHV-8 antibodies and the study was restricted to 2191 HIV-1 antibody-negative patients. We examined the relationship between infection with HHV-8 and sociodemographic and behavioural factors using unconditional logistic regression models. Of the 2191 HIV-1 negative patients who did not have Kaposi's sarcoma, 854 (39·1%) were positive for antibodies against the latent nuclear antigen of HHV-8 encoded by orf73 in a immunofluorescence assay. Infection with HHV-8 was independently associated with increasing age (P trend=0·02). For females, independent risk factors also included working in a paid domestic capacity (OR 1·63, 95% CI 1·09–2·44, P=0·02), defining occupational status as economically non-active unemployed (OR 1·70, 95% CI 1·06–2·72, P=0·03), having a state pension or being on a disability grant (OR 1·49, 95% CI 1·05–2·11, P=0·02), using oral contraceptives (OR 1·43, 95% CI 1·03–1·99, P=0·03) and having a delayed age at menarche (P trend=0·04). The relationship between these variables and HHV-8 antibody status requires further, prospective study.

Type
Short Report
Information
Epidemiology & Infection , Volume 132 , Issue 6 , December 2004 , pp. 1191 - 1197
Copyright
© 2004 Cambridge University Press