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Longitudinal study of toxoplasma seroprevalence in South Yorkshire

Published online by Cambridge University Press:  15 May 2009

J. Walker ,
D. J. Nokes  and
R. Jennings
J. Walker
Affiliation:
Parasite Epidemiology Research Group, Department of Biology, Imperial College, Prince Consort Road, London SW7 2BB
D. J. Nokes
Affiliation:
Parasite Epidemiology Research Group, Department of Biology, Imperial College, Prince Consort Road, London SW7 2BB
R. Jennings
Affiliation:
Section of Virology, Department of Experimental and Clinical Microbiology, Sheffield University Medical School, Sheffield
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Serum samples collected from individuals of a wide range of ages in South Yorkshire between 1969 and 1990 provided the basis for a longitudinal seroprevalence survey of Toxoplasma gondii antibodies. Sera numbering 3868 were screened for T. gondii specific antibodies using a commercial latex agglutination test. The resultant temporal series of serological profiles revealed a rise, with age, in seroprevalence, the rate of which showed a decrease through time. A plateau of around 40–50% prevalence was attained by the 41- to 45-year age-class in 1969 which was not approached until the 66- to 70-year class in the 1988–90 data set. This trend for decline in seroprevalence was confirmed by statistical analysis for the age range 21–60 years. These results may be indicative of a decrease in the rate of toxoplasma exposure in this study community over the 20-year period. The survey of 1988–90 provides a base-line profile of present-day seroprevalence in which 11 % of individuals in the age range 16–45 years (roughly corresponding to the childbearing age-range) show evidence of past infection. The representative nature of the serum collection and public-health implications of these results are discussed.

Type
Research Article
Information
Epidemiology & Infection , Volume 108 , Issue 1 , February 1992 , pp. 99 - 106
Copyright
Copyright © Cambridge University Press 1992

References

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