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Longitudinal study of rotavirus infections among children from Belém, Brazil

Published online by Cambridge University Press:  15 May 2009

A. C. Linhares ,
Y. B. Gabbay ,
R. B. Freitas ,
E. S. Travassos da Rosa ,
J. D. P. Mascarenhas  and
E. C. B. Loureiro
A. C. Linhares
Affiliation:
Instituto Evandro Chagas, Fundação, Serviços de Saúde, Publica, Ministério da Saúde, Belém, Pará, Brasil
Y. B. Gabbay
Affiliation:
Instituto Evandro Chagas, Fundação, Serviços de Saúde, Publica, Ministério da Saúde, Belém, Pará, Brasil
R. B. Freitas
Affiliation:
Instituto Evandro Chagas, Fundação, Serviços de Saúde, Publica, Ministério da Saúde, Belém, Pará, Brasil
E. S. Travassos da Rosa
Affiliation:
Instituto Evandro Chagas, Fundação, Serviços de Saúde, Publica, Ministério da Saúde, Belém, Pará, Brasil
J. D. P. Mascarenhas
Affiliation:
Instituto Evandro Chagas, Fundação, Serviços de Saúde, Publica, Ministério da Saúde, Belém, Pará, Brasil
E. C. B. Loureiro
Affiliation:
Instituto Evandro Chagas, Fundação, Serviços de Saúde, Publica, Ministério da Saúde, Belém, Pará, Brasil
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From December 1982 to March 1986 a group of 80 children between 0 and 3 years old who lived in the peripheral area of Belém, Brazil, were followed up for episodes of diarrhoea. A total of 441 diarrhoeal episodes were recorded and 36 (8·2%) were associated with rotavirus. This agent was the only pathogen in 50% of rotavirus-related episodes of acute diarrhoea, and strains were characterized by analysis of RNA in polyacrylamide gels. Forty-one belonged to subgroup II (long pattern) and five to subgroup I. Reinfections by rotavirus were noted in 12 children involving either the same or different subgroups. Ten distinct electrophoretypes were detected in the study period and the predominant one had the ‘1N2L’ profile. The cumulative age-specific attack rate for diarrhoea reached 2–8 by the end of the first year of life; a frequency of 2–3 episodes of diarrhoea per child per year was observed throughout the complete investigation. In comparing the age-specific attack rates for diarrhoea between breast-fed and bottle-fed children, a peak at 6 months of age was noted in the former, and at 1 month in the latter. A comparison by Fischer's exact test (P = 0·21) provided no evidence for protection against clinical rotavirus disease by maternal milk. By the same test, however (P = 0·021), we found significant evidence that early rotavirus infections were more likely to be asymptomatic and that infections after 4 months were more likely to be symptomatic. The clinical picture in children with rotavirus-related diarrhoea was more severe than in those suffering from acute diarrhoea due to another agent.

Type
Research Article
Information
Epidemiology & Infection , Volume 102 , Issue 1 , February 1989 , pp. 129 - 145
Copyright
Copyright © Cambridge University Press 1989

References

REFERENCES

Baldacci, E. R., Candeias, J. A. N., Brevigliere, J. G. & Grisi, S. J. E. (1979). Etiologia viral e bacteriana de casos de gastroenterite infantil: uma caracterização clinica. Revista de Saúde Pública, São Paulo 13, 47–53.CrossRefGoogle Scholar
Beards, G. M. (1987). Serotyping of rotaviruses by NADP-enhanced -enzyme-immunoassay. Journal of Virological Methods 18, 77–85.CrossRefGoogle ScholarPubMed
Beards, G. M., Campbell, A. D., Cottrell, N. R., Peiris, J. S. M., Rees, N., Sanders, R. C., Shirley, J. A., Wood, H. C. & Flewett, T. H. (1984). Enzyme-linked immunosorbent assays based on polyclonal and monoclonal antibodies for rotavirus detection. Journal of Clinical Microbiology 191, 248–254.CrossRefGoogle Scholar
Bishop, R. F., Barnes, G. L., Cipriani, E. & Lund, J. (1983). Clinical immunity after neonatal rotavirus infection. A prospective longitudinal study in young children. New England Journal of Medicine 309, 72–76.CrossRefGoogle ScholarPubMed
Clemens, J. P., Ahmed, M., Butler, T., Greenough, W. B. III, Sack, D. A. & Stanton, B. F. (1983). Rotavirus diarrhoea; an expanding clinical spectrum. Journal of Tropical Medicine and Hygiene 83, 117–122.Google Scholar
Coelho, C. A. R., Moreira, F. L., Maffei, H. V. L. & Coelho, K. I. R. (1983). Incidência de partículas virais em crianças com diarréia aguda ou protraída, atendidas no Hospital das Clinicas da Faculdade de Medicina de Botucatu, no período de fevereiro de 1980 a fevereiro de 1981. Revista do Instituto de Medicina Tropical de São Paulo 25, 113–119.Google Scholar
Coiro, J. R. R., De Almeida Neto, A. J., Heuser, M. C. F., Bendati, M. M. A. & Vasconcelos, V. L. (1985). Acute enteritis associated with rotavirus presence in Brazilian children; evaluations on prevalence, therapy and age group. Journal of Diarrhoeal Diseases Research 3, 78–83.Google ScholarPubMed
Davidson, G. P., Townley, R. R. W., Bishop, R. F. & Holmes, I. H. (1975). Importance of a new virus in acute sporadic enteritis in children. Lancet 1; 242–251.Google ScholarPubMed
Edwards, P. R. & Ewing, W. H. (1972). Identification of Enterobacteriaceae, 3rd ed.Minneapolis, Minnesota: Burgess Publishing Company.Google Scholar
Fonteyne, J., Zissis, G. & Lambert, J. P. (1978). Recurrent rotavirus gastroenteritis. Lancet 1, 983.CrossRefGoogle ScholarPubMed
Guerrant, R. L., Kirchoff, L. V., Shields, D. S., Nations, M. K., Leslie, J., Souza, M. A., Araujo, J. E., Correia, L. L., Sauer, K. T., Mc Clelland, K. E., Trowbridge, T. L. & Hughes, J. M. (1983). Prospective study of diarrhoeal illnesses in Northeastern Brazil: patterns of disease, nutritional impact, etiology and risk factors. Journal of Infectious Diseases 148, 986–997.CrossRefGoogle ScholarPubMed
Gurwith, M., Wenman, W., Gurwith, D., Brunton, J., Feltham, S. & Greenberg, H. (1983).Diarrhoea among infants and young children in Canada: a longitudinal study in three Northern communities. Journal of Infectious Diseases 147, 185–192.CrossRefGoogle Scholar
Kapikian, A. Z., Kim, H. W., Wyatt, R. G., Cline, W. L., Arrobio, J. O., Brandt, C. D., Rodriguez, W. J., Sack, D. A., Chanock, R. M. & Parrott, R. H. (1976). Human reovirus-like agent as the major pathogen associated with ‘winter’ gastroenteritis in hospitalized infants and young children. New England Journal of Medicine 294, 965–972.CrossRefGoogle ScholarPubMed
Konno, T., Suzuki, H., Matsushima, N., Imai, A., Tazawa, F., Kutsuzawa, T., Kitaoka, S., Sakamoto, M., Yazaki, N. & Ishida, N. (1983). Influence of temperature and relative humidity on human rotavirus infection in Japan. Journal of Infectious Diseases 147, 125–128.CrossRefGoogle ScholarPubMed
Linhares, A. C., MoncÃo, H. C., Gabbay, Y. B., De Araujo, V. L. C., Serruya, A. C. & Loureiro, E. C. B. (1983). Acute diarrhoea associated with rotavirus among children living in Belém, Brazil. Transactions of the Royal Society of Tropical Medicine and Hygiene 77, 384–390.CrossRefGoogle ScholarPubMed
Linhares, A. C., Pinheiro, F. P., Schmetz, C., MÜller, G., Peters, D., Freitas, R. B. (1982). Rotavirus em Belém do Pará, Brasil (Estudo piloto) Revista do Instituto de Medicina Tropical de São Paulo 24, 292–297.Google Scholar
Linhares, A. C., Pinheiro, F. P., Freitas, R. B., Gabbay, Y. B., Shirley, J. A., Beards, G. M. (1981). An outbreak of rotavirus diarrhoea among a non-immune isolated South American Indian community. American Journal of Epidemiology 113, 703–710.CrossRefGoogle Scholar
Linhares, A. C., Salbé, E. V., Gabbay, Y. B. & Rees, N. (1986). Prevalence of rotavirus antibody among isolated South American Indian communities. American Journal of Epidemiology 123, 699–709.CrossRefGoogle ScholarPubMed
Lourenço, M. H., Nicolas, J. C., Cohen, J., Scherrer, R. & Bricout, F. (1982). Study of human rotavirus genome by electrophoresis: attempt of classification among strains isolated in France. Annales de Virologie 73, 219–230.Google Scholar
Mata, L., Simhon, A., Padilla, R., Gamboa, M. del M., Vargas, G., Hernandez, F., Mohs, E. & Lizano, C. (1983a). Diarrhoea associated with rotavirus, enteropathogenic E. coli. Campylobacter, and another in Costa Rica children. American Journal of Tropical Medicine and Hygiene 32, 146–153.CrossRefGoogle Scholar
Mata, L., Simhon, A., Urrutia, J. J., Kronmal, R. A., Férnandez, R. & Garcia, B. (1983b). Epidemiology of rotaviruses in a cohort of 45 Guatemalan Mayan Indian children observed from birth to the age of three years. Journal of Infectious Diseases 148, 452–461.CrossRefGoogle Scholar
Melnick, J. L. & Wenner, H. A. (1969). Enteroviruses. In: Diagnostic procedures for viral and rickettsial infections. ed. Lennett, E. & Schmidt, N. J.4th ed. pp. 529–602. New York; American Public Health Association, 17.Google Scholar
Moosai, R. B., Alcock, R. & Madeley, C. R. (1984). A cryptogram for recording rotavirus strains: the Rotacode. Journal of Hygiene 93, 237–250.Google ScholarPubMed
Paul, M. O. & Erinle, E. A. (1982). Rotavirus infection in Nigerian infants and young children with gastroenteritis. American Journal of Tropical Medicine and Hygiene 31, 374–375.CrossRefGoogle Scholar
Pereira, H. G., Azeredo, R. S., Leite, J. P. G., Candeias, J. A. N., Rãcz, M. L., Linhares, A. C., Gabbay, Y. B. & Trabulsi, J. R. (1983). Electrophoretic study of the genome of human rotaviruses from Rio de Janeiro, São Paulo and Pard, Brazil. Journal of Hygiene 90, 117–125.CrossRefGoogle Scholar
Rodriguez, W. J., Kim, H. W., Brandt, C. D., Yolken, R. H., Arrobio, J. O., Kapikian, A. Z., Chanock, R. M. & Parrott, R. H. (1978). Sequential enteric illnesses associated with different rotavirus serotypes. Lancet 2, 37.CrossRefGoogle ScholarPubMed
Svennerholm, A. M. & Holmgren, J. (1978). Identification of Escherichia coli heat-labile enterotoxin by means of a ganglioside immunosorbent assay (GM1-ELISA). Current Microbiology 1, 19–23.CrossRefGoogle Scholar
Totterdell, B. M., Chrystie, I. L. & Banatvala, J. E. (1980). Cord blood and breast-milk antibodies in neonatal rotavirus infection. British Medical Journal 1, 828–830.Google Scholar
Totterdell, B. M., Nicholson, K. G., MacLeod, J., Chrystie, I. L. & Banatvala, J. E. (1982). Neonatal rotavirus infection: role of lacteal neutralizing alpha 1 anti-trypsin and non-immunoglobulin anti-viral activity protection. Journal of Medical Virology 10, 37–44.CrossRefGoogle Scholar
Yolken, R. H., Wyatt, R. G., Kim, W. H., Kapikian, A. Z. & Chanock, R. M. (1978).Immunological response to infection with human reovirus-like agent immunoglobulin G and M levels by the method of enzyme-linked immunosorbent assay. Infection and Immunity 19, 540–546.CrossRefGoogle Scholar
World health organization diarrhoeal diseases control programme. Report of the Third Meeting of the Scientific Working Groups on Viral Diarrhoeas: Microbiology, Epidemiology, Immunology and Vaccine Development (WHO/CDD/UID/ 84.4) Geneva, 1–3 02 1984.Google Scholar
World health organization. (1985) The management of diarrhoea and use of oral rehydration therapy. A joint WHO/UNICEF statement, 1983, 2nd ed.Geneva: World Health Organization.Google Scholar
Wyatt, R. G., Yolken, R. H., Urrutia, J. J., Mata, L., Greenberg, H. B., Chanock, R. M. & Kapikian, A. Z. (1979). Diarrhoea associated with rotavirus in rural Guatemala: a longitudinal study of 24 infants and young children. American Journal of Tropical Medicine and Hygiene 28, 325–328.CrossRefGoogle ScholarPubMed