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The incidence of complement-fixing antibody to varicella-zoster virus in hospital patients and blood donors

Published online by Cambridge University Press:  15 May 2009

A. H. Tomlinson  and
F. O. MacCallum
A. H. Tomlinson
Affiliation:
Public Health Laboratory, Radcliffe Infirmary, Oxford
F. O. MacCallum
Affiliation:
Virology Laboratory, Radcliffe Infirmary, Oxford
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Summary

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The sera of 308 patients, not suffering from varicella or zoster infections, and the sera of 183 blood donors were examined for complement-fixing antibody to varicella-zoster virus. In both groups about 70% of sera from persons aged 11–40 years had antibody titres ≥ 1/4; the incidence was less in the age range 41–60 years and increased in later decades. Antibody titres of 1/16 or 1/32 were noticeably less frequent in those aged 41–60 years than in younger or older groups.

It was concluded that an unchanging titre of 1/16 or 1/32 was of no diagnostic significance. The age distribution of antibody was consistent with the theory that zoster only occurs when antibody has declined.

Type
Research Article
Information
Journal of Hygiene , Volume 68 , Issue 3 , September 1970 , pp. 411 - 416
Copyright
Copyright © Cambridge University Press 1970

References

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