Hostname: page-component-586b7cd67f-2plfb Total loading time: 0 Render date: 2024-11-23T21:52:46.388Z Has data issue: false hasContentIssue false
  • English
  • Français

Immunoglobulin A antibodies directed against Campylobacter jejuni flagellin present in breast–milk

Published online by Cambridge University Press:  15 May 2009

I. Nachamkin ,
S. H. Fischer ,
X.-H. Yang ,
O. Benitez  and
A. Cravioto
I. Nachamkin
Affiliation:
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, Pennsylvania 19104–4283
S. H. Fischer
Affiliation:
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, Pennsylvania 19104–4283
X.-H. Yang
Affiliation:
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, Pennsylvania 19104–4283
O. Benitez
Affiliation:
Departamento de Salud Pública, Facultad de Medicina, Universidad Nacional Autónoma de México, México, D.F. 04510, México
A. Cravioto
Affiliation:
Departamento de Salud Pública, Facultad de Medicina, Universidad Nacional Autónoma de México, México, D.F. 04510, México
Rights & Permissions [Opens in a new window]

Summay

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

We studied the relationship between IgA anti–campylobacter flagellin antibodies in breast milk samples and protection of breastfed infants living in a rural Mexican village from campylobacter infection. There were fewer episodes of campylobacter infection (symptomatic and asymptomatic combined) in infants breastfed with milk containing specific anti-flagellin antibodies (1.2/child/year, 95% CI 0.6–1.8) versus non–breastfed children (3.3/child/year, 95% CI 1.8–4.8; P < 0.01). Infants breastfed with milk that was antiflagellin antibody negative by ELISA also had fewer episodes of infection compared with non-breastfed children, but the difference did not reach statistical significance (1.8/child/year, 95% CI 0.7–3.0 versus 3.3/child/year, 95% CI 1.8–4.8, P > 0.05). Breastfeeding has a protective effect against campylobacter infection and is associated with the presence of specific antibodies directed against campylobacter flagellin.

Type
Research Article
Information
Epidemiology & Infection , Volume 112 , Issue 2 , April 1994 , pp. 359 - 365
Copyright
Copyright © Cambridge University Press 1994

References

REFERENCES

Nachamkin, I, Hart, AM. Western blot analysis of the human antibody response to Campylobacter jejuni cellular antigens during gastrointestinal infection. J Clin Microbiol 1985; 21: 33–8.CrossRefGoogle ScholarPubMed
Nachamkin, I, Yang, XH. Human antibody response to Campylobacter jejuni flagellin protein and a synthetic N–terminal flagellin peptide. J Clin Microbiol 1989; 27: 2195–8.CrossRefGoogle Scholar
Wenman, WM, Chai, J, Louie, TJ et al. . Antigenic analysis of Campylobacter flagellar protein and other proteins. J Clin Microbiol 1985; 21: 108–12.CrossRefGoogle ScholarPubMed
Blaser, MJ, Black, RE, Duncan, DJ, Amer, J. Campylobacter jejuni specific serum antibodies are elevated in healthy Bangladeshi children. J Clin Microbiol 1985; 21: 164–7.CrossRefGoogle ScholarPubMed
Black, RE, Levine, MM, Clements, ML, Hughes, TP, Blaser, MJ. Experimental Campylobacter jejuni infections in humans. J Infect Dis 1988; 157: 472–80.CrossRefGoogle Scholar
Martin, PMV, Mathiot, J, Ipero, J, Kirimat, M, Georges, AJ, Georges-Courbot, MC. Immune response to Campylobacter jejuni and Campylobacter coli in a cohort of children from birth to 2 years of age. Infect Immun 1989; 57: 2542–6.CrossRefGoogle Scholar
Ueki, Y, Umeda, A, Fujimoto, S, Mitsuyama, M, Amako, K. Protection of Campylobacter jejuni infection in suckling mice by anti–flagellin antibodies. Microbiol Immunol 1987; 31: 1161–71.CrossRefGoogle Scholar
Glass, RI, Svennerholm, A, Stoll, BJ. Milk antibodies protect breastfed children against cholera. N Engl J Med 1983; 308: 1389–92.CrossRefGoogle ScholarPubMed
Clemens, JD, Stanton, B, Stoll, B, Shahid, NS, Banu, H, Chowdhury, AKMA. Breast feeding as a determinant of severity in shigellosis. Am J Epidemiol 1986; 123: 710–20.CrossRefGoogle ScholarPubMed
Duffy, LC, Byers, TE, Riepenhoff-Talty, M, la Scolea, LJ, Zielenzny, M, Ogra, PL. The effects of infant feeding on rotavirus–induced gastroenteritis: a prospective study. Am J Public Health 1986; 76: 269–63.CrossRefGoogle ScholarPubMed
Megraud, F, Boudraa, G, Bessaoud, K et al. , Incidence of campylobacter infection in infants in western Algeria and the possible protective role of breast feeding. Epidemiol Infect 1990; 105: 73–8.CrossRefGoogle ScholarPubMed
Ruiz-Palacios, GM, Calva, JJ, Pickering, LK et al. , Protection of breast–fed infants against Campylobacter diarrhea by antibodies in human milk. J Pediatr 1990; 116: 707–13.CrossRefGoogle ScholarPubMed
Cravioto, A, Reyes, RE, Trujillo, F et al. , Risk of diarrhea during the first year of life associated with initial and subsequent colonization by specific enteropathogens. Am J Epidemiol 1990: 131: 886–904.CrossRefGoogle ScholarPubMed
Cravioto, A, Reyes, RE, Ortega, R, Fernandez, G, Hernandex, R, Lopez, D. Prospective study of diarrheal disease in a cohort of rural Mexican children: incidence and isolated pathogens during the first two years of life. Epidem Infect 1988; 101: 123–34.CrossRefGoogle Scholar
Hennart, PF, Brasseur, DJ, Delogne-Desnoeck, JB, Dramaix, MM, Robyn, CE. Lysozyme, lactoferrin, and secretory immunoglobulin A content in breast milk: influence of duration of lactation, nutrition status, prolactin status, and parity of mother. Am J Clin Nutr 1991; 53: 32–9.CrossRefGoogle ScholarPubMed
Chang, S. Antimicrobial proteins of maternal and cord sera and human milk in relation to maternal nutritional status. Am J Clin Nutr 1990; 51: 183–7.CrossRefGoogle ScholarPubMed
Renom, G, Kirimat, M, Georges, AJ, Philippe, JC, Martin, PM. High levels of anti-Campylobacter flagellin IgA antibodies in breast milk. Res Microbiol 1992; 143: 93–8.CrossRefGoogle ScholarPubMed
Cleary, TG, Winsor, DK, Reich, D, Ruiz-Palacios, G, Calva, JJ. Human milk immunoglobulin A antibodies to Shigella virulence determinants. Infect Immun 1989; 57: 1675–9.CrossRefGoogle ScholarPubMed
Cravioto, A, Tello, A, Villafan, H, Ruiz, J, del Vedovo, S, Neeser, JR. Inhibition of localized adhesion of enteropathogenic Escherichia coli to HEp-2 cells by immunoglobulin and oligosaccharide fractions of human colostrum and breast milk. J Infect Dis 1991; 163: 1247–55.CrossRefGoogle ScholarPubMed
Gibbons, RA, Sellwood, R, Burrows, M, Hunter, PA. Inheritance of resistance to neonatal E. coli diarrhea in the pig: examination of the genetic system. Theor Appl Genet 1977; 51: 65–70.CrossRefGoogle ScholarPubMed
Sellwood, R. Escherichia coli diarrhea in pigs with and without the K88 receptor. Vet Rec 1979; 105: 228–30.CrossRefGoogle ScholarPubMed
Isaacson, RE, Dean, EA, Morgan, DL, Moon, HW. Immunization of suckling pigs against enterotoxigenic Escherichia coli–induced diarrheal disease by vaccinating dams with purified K99 or 987P pili: antibody production in response to vaccination. Infect Immun 1980; 29: 824–6.CrossRefGoogle ScholarPubMed
Jason, JM, Nieburg, P, Marks, JS.. Mortality and infectious diseases associated with infant–feeding practices in developing countries. Pediatr 1984; 74(S): 702–27.CrossRefGoogle ScholarPubMed