Hostname: page-component-745bb68f8f-cphqk Total loading time: 0 Render date: 2025-01-12T02:55:09.308Z Has data issue: false hasContentIssue false
  • English
  • Français

Immunization of man with typhoid and cholera vaccine. Agglutinating antibodies after intracutaneous and subcutaneous injection

Published online by Cambridge University Press:  15 May 2009

H. A. L. Clasener  and
B. J. W. Beunders
H. A. L. Clasener
Affiliation:
Institute of Tropical Hygiene, Leiden, The Netherlands
B. J. W. Beunders
Affiliation:
Director Royal Netherlands Army and Airforce Health Department Medical Service, The Hague, The Netherlands
Rights & Permissions [Opens in a new window]

Extract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Young men were immunized against cholera, typhoid, paratyphoid A, and paratyphoid B. Agglutinating antibodies were measured 3 weeks after completion of the immunization schedule. Two injections separated by a 4-week interval were found to be as efficient as three injections with 1-week intervals.

Intracutaneous immunization with one-fifth of the standard subcutaneous dose was just as efficient as the standard subcutaneous immunization and did not cause greater general or local reaction.

Type
Research Article
Information
Journal of Hygiene , Volume 65 , Issue 4 , December 1967 , pp. 449 - 456
Copyright
Copyright © Cambridge University Press 1967

References

REFERENCES

Ashcroft, M. T., Morrison, R. J., Nicholson, C. C. & Stuart, C. A. (1964). Antibody responses to vaccination of British Guiana schoolchildren with heat-killed phenolized and acetone-killed lyophilized typhoid vaccines. Am. J. Hyg. 80, 221.Google Scholar
Bardhan, P. N., Dutta, H. N. & Krishnaswami, P. (1963). Intradermal TAB immunization against enteric infections. J. Hyg., Camb. 61, 365.CrossRefGoogle ScholarPubMed
Barr, M., Sayers, M. H. P. & Stamm, W. P. (1959). Intradermal TABT vaccine for immunisation against enteric. Lancet i, 816.CrossRefGoogle Scholar
Benenson, A. S. (1964). Serological responses of man to typhoid vaccines. Bull. Wld Hlth Org. 30, 693.Google Scholar
Birkhaug, K. & Böe, J. (1946). Intradermal spread of vital dye in anaphylaxis and bacterial allergy. J. Immun. 54, 107.Google Scholar
Chiang, Yü-T'u & Ch'en, Tschung-Hsien (1958). Reaction and immune response to typhoid and paratyphoid vaccines of different dosage and routes of injection. Chin. med. J. 76/4, 47.Google ScholarPubMed
Clasener, H. A. L. (1967). Immunization of man with salmonella vaccine and tetanus- diphthera vaccine. Dose–response relationship, secondary response and competition of antigens. J. Hyg., Camb. 65, 457.Google Scholar
Felix, A. (1938). The titration of therapeutic and anti-typhoid serum. J. Hyg., Camb. 38, 750.Google ScholarPubMed
Gardner, A. D. (1937). An international experiment on the widal-reaction. J. Hyg., Camb. 37, 124.CrossRefGoogle ScholarPubMed
Hudack, S. S. & McMaster, P. D. (1933). The lymphatic participation in human cutaneous phenomena. A study of the minute lymphatics of the living skin. J. exp. Med. 57, 751.CrossRefGoogle ScholarPubMed
Kheifetz, L. B. & Khazanov, M. I. (1959). A method for the epidemiological study of N11S1 polyvalent vaccine. J. Microbiol. Epidem. Immunobiol. 30/11, 55.Google Scholar
Korngold, L., Stahl, G. L., Dodd, M. C. & Myers, W. G. (1953). The comparative retention of antigen in the skin of immune and normal rabbits as determined with egg albumin labelled with radioactive iodine. J. Immun. 70, 345.Google Scholar
Leskowitz, S. & Waksman, B. H. (1960). Studies in immunization. I. The effect of route of injection of bovine serum albumin in Freund adjuvant on production of circulating antibody and delayed hypersentivity. J. Immun. 84, 58.CrossRefGoogle Scholar
Lidwell, O. M. (1963). Methods of investigation and analysis of results. In Infection in Hospitals, Ed. Williams, and Shooter, . Oxford: Blackwell Scientific Publications.Google Scholar
Longfellow, D. & Luippold, G. F. (1940). Typhoid vaccination studies. Revaccination and duration of immunity. Am. J. publ. Hlth 30, 1311.CrossRefGoogle ScholarPubMed
Luippold, G. F. (1944). Typhoid vaccine studies. IX. Intracutaneous versus subcutaneous vaccination for initial immunization. Am. J. publ. Hlth 34, 1151.CrossRefGoogle ScholarPubMed
McMaster, P. D. & Parsons, R. J. (1950). The movement of substances and the state of the fluid in the intradermal tissue. Ann. N.Y. Acad. Sci. 52, 997.CrossRefGoogle ScholarPubMed
Morgan, H. R., Favorite, G. O. & Horneff, J. A. (1943). Immunizing potency in man of a purified antigenic material isolated from Eberthella typhosa. J. Immun. 46, 301.CrossRefGoogle Scholar
Noble, J. E. (1963). Reaction to intradermal TABT and TAB vaccines. Jl. R.Army med. Cps. 109, 178.Google Scholar
Noble, J. E. (1964). Intradermal cholera vaccination. J. Hyg., Camb. 62, 11.Google Scholar
Noble, J. E. & Fielding, P. (1965). Combined enteric and cholera vaccination by the intradermal route. J. Hyg., Camb. 63, 345.CrossRefGoogle ScholarPubMed
Perry, R. M. (1937). Comparison of typhoid O and H agglutinin responses following intracutaneous and subcutaneous inoculation of typhoid, paratyphoid A and B vaccine. Am. J. Hyg. 26, 388.Google Scholar
Rusznyak, I., Foldi, M. & Szabo, G. (1960). Lymphatics and Lymph Circulation. Pergamon Press.Google Scholar
Shi, P'Eng-ta (1958). The use of concentrated typhoid vaccine for intradermal immunization. Chin. med. J. 77/1, 27.Google Scholar
Siler, J. F. & Dunham, G. C. (1939). Duration of immunity conferred by typhoid vaccine. Results of revaccination by intracutaneous injection of typhoid vaccine. Am. J. publ. Hlth 29, 95.Google Scholar
Singer, E., Weis, H. & Hoa, S. H. (1948). Cholera immunization. J. Immun. 60, 181.Google Scholar
Singh, G. & Ahuja, M. L. (1951). A new test for the identification of roughness in vibrio cholerae. Indian J. med. Res. 39, 417.Google Scholar
Standfast, A. F. B. (1964). The correlation of properties in vitro with host-parasite relations. Symp. Soc. gen. Microbiol. no. 14. Microbial behaviour ‘in vivo’ and ‘in vitro’.Google Scholar
Stevens, K. M. (1956). Some considerations of the antigen dose–antibody response relationship. J. Immun. 76, 187.Google Scholar
Stills, W. T. (1960). Influenza antigen dose and antibody response relationships. J. Bact. 80, 570.CrossRefGoogle Scholar
Tuft, L. (1931). The skin as an immunological organ. (With results of experimental investigations and review of the literature.) J. Immun. 21, 85.Google Scholar
Tuft, L., Yagle, E. M. & Rogers, S. (1932). Comparative study of the antibody response after various methods of administration of mixed typhoid vaccine. J. infect. Dis. 50, 98.CrossRefGoogle Scholar
Valentine, E., Park, W. H., Talk, K. G. & McGuire, G. (1935). A study of agglutinin response to typhoid vaccine. Am. J. Hyg. 22, 44.Google Scholar
Vella, E. E. & Fielding, P. (1963). Note on the agglutinability of cholera suspensions. Trans. R. Soc. trop. Med. Hyg. 57, 112.CrossRefGoogle ScholarPubMed
Vella, E. E. (1963). Cholera vaccines and the El Tor vibrio. Br. med. J. i, 1203.CrossRefGoogle Scholar
Waksman, B. H. & Morrison, L. R. (1951). Tuberculin type sensitivity to spinal cord antigen in rabbits with isoallergic encephalomyelitis. J. Immun. 66, 421.Google Scholar
Waksman, B. H. (1956). Further study of skin reactions in rabbits with experimental allergic encephalomyelitis. J. infect. Dis. 99, 258.CrossRefGoogle ScholarPubMed
Yugoslav Typhoid Commission (1962). A controlled field trial of the effectiveness of phenol and alcohol typhoid vaccines. Final report. Bull. Wld Hlth Org. 26, 357.Google Scholar
Zinn, W. & Katz, G. (1927). Eimvirkung von der Haut auf den gesunden und tuberkulösen Organismus. Leipzig.Google Scholar