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Immunity of Guinea-pigs to Diphtheria Toxin and its Effect upon the Offspring

Published online by Cambridge University Press:  15 May 2009

H. J. Südmersen  and
A. T. Glenny
H. J. Südmersen
Affiliation:
(From the Wellcome Physiological Research Laboratories, Brockwell Hall, Herne Hill, London, S.E.)
A. T. Glenny
Affiliation:
(From the Wellcome Physiological Research Laboratories, Brockwell Hall, Herne Hill, London, S.E.)
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1. Diphtheria toxin-antitoxin mixtures induce a higher immunity in guinea-pigs than sub-lethal doses of toxin; one injection of the mixture being sufficient to produce an immunity lasting in some cases for a period of over two years, as shown by the passive immunity conferred on the offspring.

2. The highest immunity is produced by toxin-antitoxin mixtures containing the most uncombined toxoid.

3. The active immunity of the mother is transferred passively to the offspring.

4. The passive immunity thus transferred usually disappears at the end of two months after birth, and only in rare instances has been recongnised after three months.

5. Immunity is mainly transmitted in utero, and only to a slight extent during lactation.

6. Young bred from does that have been used for a single routine antitoxin test may be able to tolerate 14 times the does of diphtheria toxin fatal for a normal guinea-pig.

Type
Research Article
Information
Journal of Hygiene , Volume 11 , Issue 2 , July 1911 , pp. 220 - 234
Copyright
Copyright © Cambridge University Press 1911

References

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