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Further studies in the mouse intra-oral inoculation technique

Published online by Cambridge University Press:  15 May 2009

S. S. Epstein  and
K. Stratton
S. S. Epstein
Affiliation:
Department of Pathology, Institute of Laryngology and Otology, London
K. Stratton
Affiliation:
Physics Department, Royal Free Hospital School of Medicine, London
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The immediate dispersal of a fluid delivered to anaesthetized mice by the intranasal and intra-oral techniques has been studied by means of a radio-active tracer method. The results clearly show that the intra-orally inoculated animal accepts a larger proportion of the total volume inoculated and that a significantly higher fraction of this reaches the lungs than in mice inoculated by the intra-nasal technique.

The authors would like to thank Dr I. Friedmann and Dr H. A. B. Simons for having made this work possible; also, Mr D. Arnott for a generous gift of labelled di-iodofluorescein, and Dr D. A. Osborn and Dr K. Weinbren for helpful suggestions.

Type
Research Article
Information
Journal of Hygiene , Volume 56 , Issue 1 , March 1958 , pp. 80 - 83
Copyright
Copyright © Cambridge University Press 1958

References

REFERENCES

Epstein, S. S. (1958). J. Hyg., Camb., 56, 73.CrossRefGoogle Scholar
Hoyle, L. & Orr, J. W. (1945). J. Path. Bact. 57, 441.CrossRefGoogle Scholar