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Factors influencing oral carriage of yeasts among individuals with diabetes mellitus

Published online by Cambridge University Press:  15 May 2009

F. Z. Aly ,
C. C. Blackwell ,
D. A. C. Mackenzie ,
D. M. Weir  and
B. F. Clarke
F. Z. Aly
Affiliation:
Department of Medical Microbiology, University of Edinburgh, Medical School Building, Teviot Place, Edinburgh EH8 9AG
C. C. Blackwell
Affiliation:
Department of Medical Microbiology, University of Edinburgh, Medical School Building, Teviot Place, Edinburgh EH8 9AG
D. A. C. Mackenzie
Affiliation:
Department of Medical Microbiology, University of Edinburgh, Medical School Building, Teviot Place, Edinburgh EH8 9AG
D. M. Weir
Affiliation:
Department of Medical Microbiology, University of Edinburgh, Medical School Building, Teviot Place, Edinburgh EH8 9AG
B. F. Clarke
Affiliation:
Department of Medical Microbiology, University of Edinburgh, Medical School Building, Teviot Place, Edinburgh EH8 9AG
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A total of 439 individuals with diabetes mellitus were examined for carriage of yeasts by the oral rinse and palatal swab techniques. Eighteen genetic or environment variables were assessed for their contribution to carriage of yeasts. The factor contributing to palatal and oral carriage of yeasts among individuals with insulin dependent diabetes mellitus (IDDM) was age (P < 0·01). The factor contributing to palatal carriage of yeasts among individuals with non-insulin dependent diabetes mellitus (NIDDM) was poor glycaemic control (glycosuria P < 0·01); carriage in the oral cavity as a whole was influenced additionally by non-secretion of ABH blood group antigens (P < 0·05). Introduction of a denture altered the above risk factors. For individuals with IDDM, oral carriage was associated with the presence of retinopathy (P < 0·05); palatal carriage was influenced by poor glycaemic control (HbA1P < 0·01, plasma glucose levels P < 0·05) and age (P < 0·05). For those with NIDDM, palatal carriage was associated with continuous presence of the denture in the mouth (P < 0·01); oral carriage was associated with plasma glucose levels (P < 0·05).

Type
Research Article
Information
Epidemiology & Infection , Volume 109 , Issue 3 , December 1992 , pp. 507 - 518
Copyright
Copyright © Cambridge University Press 1992

References

REFERENCES

1.Odds, FC. Factors that predispose the host to candidiasis. In: Candida and candidiasis: a review and bibliography. 2nd edn. Bailliére Tindall, 1988: 93–114.Google Scholar
2.Lamey, PJ. Darwazeh, A. Fisher, BM, Samaranayake, LP, McFarlane, TW, Frier, BM. Secretor status. candidal carriage and candidal infection in patients with diabetes mellitus. J Oral Pathol 1988: 17: 354–7.CrossRefGoogle ScholarPubMed
3.Tapper-Jones, LM, Aldred, MJ, Walker, DM, Hayes, TM. Candidal infections and populations of Candida albicans in mouths of diabetics. J Clin Pathol 1981; 34: 706–11.CrossRefGoogle ScholarPubMed
4.Barlow, AJE, Chattaway, FW. Observations on the carriage of C. albicans in man. Br J Dermatol 1969; 81: 103–6.CrossRefGoogle ScholarPubMed
5.Fisher, BM, Lamey, P-J, Samanayake, LP, MacFarlane, TW. Carriage of Candida species in the oral cavity in diabetic patients: relationship to glycaemic control. J Oral Pathol 1987: 16: 282–4.CrossRefGoogle ScholarPubMed
6.Hill, LVH, Tan, MH, Pereira, LH, Embil, JA. Associations of oral candidiadis with diabetic control. J Clin Pathol 1989; 42: 502–5.CrossRefGoogle Scholar
7.Burford-Mason, AP, Welsby, JCP, Willoughby, JMT. Oral carriage of C. albicans, ABO blood group and secretor status in healthy individuals. J Med Veter Mycol 1988; 26: 49–56.CrossRefGoogle Scholar
8.Blackwell, CC, Aly, FZM, James, VS, et al. Blood group, secretor status and oral carriage of yeasts among patients with diabetes mellitus. Diabetic Res 1989; 12: 101–4.Google ScholarPubMed
9.Ryley, JF. Review article: Pathogenicity of Candida albicans with particular reference to the vagina. J Med Vet Mycol 1986: 24: 5–22.CrossRefGoogle Scholar
10.Haverkorn, MJ, Goslings, WRO. Streptococci, ABO blood groups and secretor status. Am J Hum Genet 1969; 21: 360–75.Google ScholarPubMed
11.Blackwell, CC. Genetic susceptibility to infectious agents. Proc Roy Coll Phys Edin 1989; 19: 129–35.Google Scholar
12.Budtz-Jorgensen, E, Bertram, V. Denture stomatitis. I. The etiology in relation to trauma and infection. Acta Odontol Scand 1970; 28: 71–92.CrossRefGoogle ScholarPubMed
13.Mollison, PL. Blood transfusion in clinical medicine, 6th ed. Oxford: Blackwell Scientific Publications, 1976; 414–82.Google Scholar
14.Milne, LJR. Fungi. In: Practical medical microbiology, 13th ed. Edinburgh: Churchill Livingstone, 1988; 675–99.Google Scholar
15.Soammes, JV, Southam, JC. Infections of the oral mucosa. In: Oral pathology. Oxford: Oxford University Press, 1985: 153–8.Google Scholar
16.Odds, FC, Evans, EGV, Taylor, MAR, Wales, JK. Prevalence of pathogenic yeasts and humoral antibodies to Candida in diabetic patients. J Clin Pathol 1978; 31: 840–4.CrossRefGoogle ScholarPubMed
17.Darwazeh, AMG, Lamey, PL, Samaranayake, LP, et al. The relationship between colonization, secretor status and in vitro adhesion of Candida albicans to buccal epithelial cells from diabetics. J Med Microbiol 1990; 33: 43–9.CrossRefGoogle ScholarPubMed
18.Aly, FZM, Blackwell, CC, Mackenzie, DAC, et al. Chronic atrophic oral candidiasis among patients with diabetes mellitus - role of secretor status. Epidemiol Infect 1991; 106: 355–63.CrossRefGoogle ScholarPubMed
19.Dick, JD, Nerz, WG, Saral, L. Incidence of polyene-resistant yeasts recovered from clinical specimens. Antimicrob Agents Chemother 1980; 18: 158–63.CrossRefGoogle ScholarPubMed
20.Mourant, AE, Kopec, AC, Domaniewska-Sobczak, K. Blood groups and diseases. Oxford: Oxford University Press, 1978.Google Scholar
21.Marples, MJ. Microbiological studies in Western Samoa. II The isolation of yeast-like organisms from the mouth with a note of some dermatophytes isolated from lesions of Tinea corporis. Trans Roy Soc Trop Med Hyg 1960; 54: 166–70.CrossRefGoogle ScholarPubMed
22.Smits, BJ, Prior, AP, Alabaster, PG. Incidence of Candida in hospital in-patients and the effect of antibiotic therapy. Br Med J 1966; 1: 208–10.CrossRefGoogle ScholarPubMed
23.Schonheyder, H, Melbye, M, Biggar, RJ, Ebbesen, P, Neuland, CY, Stenderup, A. Oral yeast flora and Candida albicans in homosexual men. Mykosen 1984; 27: 539–44.Google ScholarPubMed
24.Warnock, DW, Hilton, AL. Value of the indirect immunofluorescence test in the diagnosis of vaginal candidiasis. Br J Vener Dis 1976; 52: 187–9.Google ScholarPubMed
25.Blackwell, CC, Weir, DM, James, VS et al. . Secretor status, smoking and carriage of Neisseria meningitidis. Epidemiol Infect 1990; 104: 203–9.CrossRefGoogle ScholarPubMed
26.Blackwell, CC, Tzanakaki, G, Kremastinou, J, et al. Factors affecting carriage of Neisseria meningitidis among Greek military recruits. Epidemiol Infect. In press.Google Scholar
27.Arendorf, TM, Walker, DM, Kingdom, RJ, Rous, JRS, Newcombe, RG. Tobacco smoking and denture wearing in oral candidal leukoplakia. Br Dent J 1983; 155: 340–3.CrossRefGoogle ScholarPubMed