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Epidemiology of mumps in the Netherlands

Published online by Cambridge University Press:  19 October 2009

J. H. T. Wagenvoort ,
M. Harmsen ,
Barry J. Khader Boutahar-Trouw ,
C. A. Kraaijeveld  and
K. C. Winkler
J. H. T. Wagenvoort
Affiliation:
Laboratory of Microbiology, State University of Utrecht, Catharijnesingel 59, 3511 GG Utrecht, The Netherlands
M. Harmsen
Affiliation:
Laboratory of Microbiology, State University of Utrecht, Catharijnesingel 59, 3511 GG Utrecht, The Netherlands
Barry J. Khader Boutahar-Trouw
Affiliation:
Laboratory of Microbiology, State University of Utrecht, Catharijnesingel 59, 3511 GG Utrecht, The Netherlands
C. A. Kraaijeveld
Affiliation:
Laboratory of Microbiology, State University of Utrecht, Catharijnesingel 59, 3511 GG Utrecht, The Netherlands
K. C. Winkler
Affiliation:
Laboratory of Microbiology, State University of Utrecht, Catharijnesingel 59, 3511 GG Utrecht, The Netherlands
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Summary

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In a Dutch population group neutralizing antibodies against mumps virus were determined by a plaque reduction technique, which proved reproducible, sensitive and specific. The results with sera of about 800 suburban children show that mumps is acquired at an early age with peak acquisition rates between the ages of four and six years. Over 90% have acquired mumps before the age of 14 years. More than 95% of about 1000 adults (18–05 years) have neutralizing antibodies. The relatively constant median titre suggests that antibodies persist during life.

During a family study 77 clinical and 18 subclinical cases were observed. In families with index cases the attack rate was 26/37 = 0·71. Eleven children (excluding six babies) esćaped infection. The mean attack rate during the epidemic was 0·30. The mean titre of mumps neutralizing antibody is maximal during the first year after the disease but declines during childhood. Mothers exposed to mumps in the family occasionally showed a significant rise in titre. Some seronegative mothers remained seronegative after exposure.

Type
Research Article
Information
Journal of Hygiene , Volume 85 , Issue 3 , December 1980 , pp. 313 - 326
Copyright
Copyright © Cambridge University Press 1980

References

REFERENCES

Black, P. J. & Houohton, W. J. (1967). The significance of mumps homagglutinin inhibition titers in normal populations. American Journal of Epidemiology 85, 101.Google Scholar
CBS, Statistisoh Zakuokk (1978). Ccntraal Bureau voor do Statistiok (Voorburg, The Netherlands).Google Scholar
CDC (Center For Disease Control) (1972). Mumps surveillance. Report no. 2.Google Scholar
CDC (Center For Disease Control) (1978). Mumps surveiHanco, July 1074-Docombcr 1970.Google Scholar
Cooney, M. K., Fox, J. P. & Hall, C. E. (1975). The Seattle Vims Watch. VI. Observations of infections with and illness duo to parainiluenza, mumps and respiratory syncytial viruses and mycoplasma pnoumoniao. American Journal of Epidemiology 101, 532.Google Scholar
Ennis, F. A. (1969). Immunity to mumps in an institutional epidemic: correlation of insusceptibility to mumps with scrum plaquo neutralizing and homagglutination-inhibiting antibodies. Journal of Infectious Diseases 119, 054.Google Scholar
Ennis, F. A., Douglas, R. D., Stewart, G. L., Horrs, H. E. & Meykr, H. M. Jr (1908). A plaquo neutralization test for determining mumps antibodies. Proceedings of the Society of Experimental Biology and Medicine 129, 800.Google Scholar
Freedman, H. A. (1976). Mumps. In Viral Infections of Humans. Epidemiologist and Control (ed. Evans, A. S.), p. 317. London, Now York: Jolin Wiley & Sons.Google Scholar
Ginsberg, H. S. & Iiorsfall, F. L. (1949). A labile component of normal scrum, which combines with various viruses. Neutralization of infectivity and inhibition of hemagglutination by the component. Journal of Experimental Medicine 90, 475.Google Scholar
Crillner, L. & Blomberg, J. (1976). Haemolysis-in-gel and neutralization tests for determination of antibodies to mumps virus. Journal of Clinical Microbiology 4, 11.Google Scholar
Hilleman, M. R. (1970). Mumps vaccination. Modern Trends in Medical Virology 2, 241.Google Scholar
Hsiung, G. D., Isacson, E. P. & Tucker, G. (1963). Studies of parainfluenza viruses. II. Sorological interrelationships in humans. Yale Journal of Biology and Medicine 35, 534.Google Scholar
Kenny, M.T., Jackson, J. E., Medler, E.M., Miller, S. A. & Osborn, R. (1976). Agorolated immunity to measles, mumps and rubella in Middle American and United States children. American Journal of Epidemiology 103, 174.Google Scholar
Kenny, M.T. & Schell, K. (1975). Microassay of measles and mumps virus and antibody in Vero colls. Journal of Biological Standardization 3, 291.Google Scholar
Lennette, E. H., Jensen, F. W., Guenther, R. W. & Magoffin, R. L. (1903). Scrologic responses to parainfluenza viruses in patients with mumps virus infection. Journal of Laboratory and Clinical Medicine 61, 780.Google Scholar
Liao, S. J. & Benenson, A. S. (1954). Immunity status of military recruits in 1951 in the United States. II. Results of mumps complement-fixation tests. American Journal of Hygiene 59, 273.Google ScholarPubMed
Mortimer, P. P. (1978). Mumps prophylaxis in thou light of a now test for antibody. British Medical Journal ii, 1523.Google Scholar
Muench, H. (1959). Catalytic Models in Epidemiology. Cambridge, Mass.: Harvard University Press.Google Scholar
Niederman, J. C, Henderson, J. R., Oiton, E. M., Black, F. L. & Skvrnova, K. (1967). A nationwide serum survey of Brazilian military recruits. 1904. II. Antibody patterns with arbevinises, polioviruses, measles and mumps. American Journal of Epidemiology 86, 319.Google Scholar
Reed, D., Buown, G., Meuiuck, R., Sever, J. & Fkltz, E. (1967). A mumps epidemic on St Georgo Island, Alaska. Journal of the American Medical Association 199, 907.Google Scholar
Sato, H., Alurecht, P., Hicks, J. T., Meyer, B. C. & Ennis, F. A. (1978). Sensitivo neutralization test for virus antibody. Archives of Virology 58, 301.Google Scholar
Stelzner, A. & Talaska, W. (1972). Epidemiologischo und serologische Mumps-analysen. Deutsches Gesundheilsucsen 27, 2083.Google Scholar
Weihel, R. E., Stokes, J. Jr, Buynak, E. B., Whitman, J. E. & Hilleman, M. R. (1907). Live, attonuatcd mumps-virus vaccino. 3. Clinical and serologic aspects in a field ovaluation. New England Journal of Medicine 276, 245.Google Scholar
Yamane, I., Matsuya, Y. & Jimbo, K. (1908). An autoclavablo powdered culture medium for mammalian colls. Proceedings of the Society of Experimental Biology and Medicine 127, 335.Google Scholar