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The effect of preadministration of Corynebacterium parvum on the protection afforded by heat-killed and acetone-killed vaccines against experimental mouse typhoid

Published online by Cambridge University Press:  15 May 2009

Sujatha Cronly-Dillon
Sujatha Cronly-Dillon
Affiliation:
Department of Bacteriology, University of Edinburgh
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Mice given an intraperitoneal injection of 0.5 mg. Corynebacterium parvum (dry weight) before vaccination with heat-killed (HK) or acetone-killed (AK) Salmonella typhimurium vaccine and later challenged intraperitoneally with S. typhimurium strain 1566, showed a statistically significant increase in mortality when compared with mice that had received only C. parvum but no vaccine. They also showed a higher mortality rate than mice receiving only HK or AK vaccine or mice that had received no vaccine before challenge. Prior administration of C. parvum to mice that are vaccinated with HK or AK vaccine appears to make them more susceptible to an intraperitoneal challenge with S. typhimurium. This was more apparent with HK vaccine than with AK vaccine.

Type
Research Article
Information
Journal of Hygiene , Volume 72 , Issue 1 , February 1974 , pp. 13 - 18
Copyright
Copyright © Cambridge University Press 1974

References

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