Hostname: page-component-586b7cd67f-t7fkt Total loading time: 0 Render date: 2024-11-23T22:05:30.875Z Has data issue: false hasContentIssue false
  • English
  • Français

The effect of an intramammary infusion of endotoxin on experimentally induced mycoplasmal mastitis

Published online by Cambridge University Press:  15 May 2009

J. Brownlie ,
C. J. Howard  and
R. N. Gourlay
J. Brownlie
Affiliation:
ARC Institute for Research on Animal Diseases, Compton, Newbury, Berks.
C. J. Howard
Affiliation:
ARC Institute for Research on Animal Diseases, Compton, Newbury, Berks.
R. N. Gourlay
Affiliation:
ARC Institute for Research on Animal Diseases, Compton, Newbury, Berks.
Rights & Permissions [Opens in a new window]

Extract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The infusion of 10 μg of endotoxin lipopolysaccharide from Escherichia coli into the mammary gland of four cows 16 h before inoculation with ureaplasmas did not prevent, or even diminish, the subsequent ureaplasmal mastitis. There was no reduction in the severity or duration of the inflammatory cell response in milk or in the clinical appearance of the resulting mastitis. Also, the excretion of ureaplasmas was not reduced.

A similar experiment with Mycoplasma dispar in two cows demonstrated that endotoxin was again ineffective in preventing the mastitis. Furthermore, there was some indication that the proliferation and excretion of this mycoplasma was enhanced in endotoxin-treated quarters.

Type
Research Article
Information
Journal of Hygiene , Volume 83 , Issue 3 , December 1979 , pp. 501 - 506
Copyright
Copyright © Cambridge University Press 1979

References

Andrews, B. E., Leach, R. H., Gourlay, R. N. & Howard, C. J. (1973). Enhanced isolation of Mycoplasma dispar by substitution of ampicillin for benzylpenicillin in growth media. Veterinary Record 93, 603.CrossRefGoogle ScholarPubMed
Blobel, H. & Katsube, Y. (1964). Effects of experimentally induced leucocytosis in bovine mammary glands upon infections with Staphylococcus aureus, Streptococcus agalactiae and Aerobacter aerogenes. American Journal of Veterinary Research 25, 1085–9.Google Scholar
Broadhurst, J. & Paley, C. (1939). A single dip stain for the direct examination of milk. Journal of the American Veterinary Medical Association.Google Scholar
Brownlie, J. (1971). Antimicrobial proteins in bovine neutrophils. Biochemical Journal 125, 81–2.Google Scholar
Brownlie, J. (1979). The effect of an intramammary infusion of endotoxin in the establishment of experimental mastitis by Streptococcus agalactiae in the cow. Journal of Hygiene 83, 103–9.CrossRefGoogle ScholarPubMed
Brownlie, J., Howard, C. J. & Gorlay, R. N. (1974). Mycoplasmacidal activity of bovine milk for T-mycoplasmas. Journal of Hygiene 73, 415–23.Google Scholar
Brownlie, J., Howard, C. J. & Gourlay, R. N. (1976). Pathogenicity of certain mycoplasma species in the bovine mammary gland. Research in Veterinary Science 20, 261–6.Google Scholar
Derbyshire, J. B. (1964). The multiplication of Staphylococcus aureus in the milk of cows with mild mastitis. Journal of Pathology and Bacteriology 87, 137–44.CrossRefGoogle ScholarPubMed
Gourlay, R. N., Howard, C. J. & Brownlie, J. (1972). The production of mastitis in cows by the intramammary inoculation of T-mycoplasmas. Journal of Hygiene 70, 511–21.Google Scholar
Gourlay, R. N. & Leach, R. H. (1970). A new mycoplasma species isolated from pneumonic lungs of calves (Mycoplasma dispar sp. nov.). Journal of Medical Microbiology 3, 111–23.Google Scholar
Howard, C. J., Brownlie, J., Gourlay, R. N. & Collins, Jacqueline (1975). Presence of a dialysable fraction in normal bovine whey capable of killing several species of bovine mycoplasmas. Journal of Hygiene 74, 261–70.CrossRefGoogle ScholarPubMed
Howard, C. J., Gourlay, R. N. & Brownlie, J. (1973). The virulence of T-mycoplasmas, isolated from various animal species, assayed by intramammary inoculation in cattle. Journal of Hygiene 71, 163–70.Google Scholar
Howard, C. J., Taylor, G., Collins, J. & Gourlay, R. N. (1976). Interaction of Mycoplasma dispar and Mycoplasma agalactiae subsp. bovis with bovine alveolar macrophages and bovine lacteal polymorphonuclear leucocytes. Infection and Immunity 14, 11–17.CrossRefGoogle Scholar
Jain, N. C., Jasper, D. E. & Dellinger, J. D. (1969). Experimental bovine mastitis due to mycoplasma. Cornell Veterinarian 59, 10–28.Google Scholar
Jasper, D. E., Bushnell, R. B. & Dellinger, J. D. (1974). Mycoplasma mastitis – a review. California Veterinarian 28, 12–14.Google Scholar
Paape, M. J. & Wergin, W. P. (1977). The leucocyte as a defense mechanism. Journal of the American Veterinary Medical Association 170, 1214–23.Google Scholar
Schalm, O. W. & Ziv-Silberman, G. (1968). Reactions following intramammary infusions of E. coli endotoxin. Veterinary Record 82, 100–3.Google Scholar