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Conversion of Bordetella pertussis to Bordetella parapertussis

Published online by Cambridge University Press:  15 May 2009

Norichika H. Kumazawa  and
Masanosuke Yoshikawa
Norichika H. Kumazawa
Affiliation:
Department of Bacterial Infection, Institute of Medical Science, University of Tokyo, Tokyo 108, Japan
Masanosuke Yoshikawa
Affiliation:
Department of Bacterial Infection, Institute of Medical Science, University of Tokyo, Tokyo 108, Japan
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The epidemiological and drug susceptibility data on whooping cough suggested a possibility that Bordetella pertussis converts in some way to Bordetella parapertussis. To prove this, B. pertussis strain 75 was treated with N-methyl-N'-nitro-N-nitrosoguanidine and a mutant resistant to staphcillin V and eight mutants resistant to trimethoprim were isolated. The staphcillin V-resistant mutant of B. pertussis agreed with all of the criteria of B. parapertussis and the trimethoprimresistant mutants also agreed with many of these criteria. Thus, a hypothesis is presented that B. parapertussis is a mutant of B. pertussis which appeared in nature probably by a selective pressure of antibiotics.

Type
Research Article
Information
Journal of Hygiene , Volume 81 , Issue 1 , August 1978 , pp. 15 - 23
Copyright
Copyright © Cambridge University Press 1978

References

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