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The clinical spectrum of human hantavirus infection in Somerset, UK

Published online by Cambridge University Press:  15 May 2009

J. V. S. Pether  and
G. Lloyd
J. V. S. Pether
Affiliation:
Public Health Laboratory, Musgrove Park Hospital, Taunton, Somerset TA1 5DB, UK
G. Lloyd
Affiliation:
Viral Diagnosis Group, PHLS Centre for Applied Microbiology and Research, Porton Down SP4 OJG, UK
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Summary

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The signs and symptoms exhibited by 29 patients with an acute illness in whom antibodies to hantavirus were detected are described. In the severe cases the most striking signs and symptoms were the persistence for 2 or 3 weeks of a severe sore throat with pyrexia that developed early in the illness, followed by swelling of the face, neck and extremities, with arthropathy and prolonged malaise that lasted for months. A macular erythematous rash, hepatomegaly with abnormal liver function tests, and a tendency to haemorrhage was a later feature of the severe cases. Mild cases presented with a variety of signs and symptoms that were very difficult to link together as a syndrome.

Type
Research Article
Information
Epidemiology & Infection , Volume 111 , Issue 1 , August 1993 , pp. 171 - 175
Copyright
Copyright © Cambridge University Press 1993

References

1.Lee, HW, Lee, PW, Johnson, KM. Isolation of the etiologic agent of Korean hemorrhagic fever. J Infect 1978; 137: 298'308.CrossRefGoogle ScholarPubMed
2.Gajdusek, DC. Muroid virus nephropathies and muroid viruses of the Hantaan group. Scand J Infect Dis 1982; 36: 96–108.Google ScholarPubMed
3.Lähdevirta, J. Nephropathia epidemica in Finland: a clinical, histological and epidemiological study. Ann Clin Res (Suppl) 1971; 3: 1–154.Google ScholarPubMed
4.Lähdevirta, J, Savola, J, Brummer-Korvenkontio, M, Berndt, R, Illikainen, R, Vaheri, A. Clinical and serological diagnosis of Nephropathia epidemica, the mild type of haemorrhagic fever with renal syndrome. J Infect 1984; 9: 230–8.CrossRefGoogle ScholarPubMed
5.Settergren, B. Nephropathia epidemica (hemorrhagic fever with renal syndrome) in Scandinavia. Rev Infect Dis 1991; 13: 736–44.CrossRefGoogle ScholarPubMed
6.Cosgriff, TM. Mechanisms of disease in hantavirus infection: pathophysiology of hemorrhagic fever with renal syndrome. Rev Inf Dis 1991; 13: 97–107.CrossRefGoogle ScholarPubMed
7.Yanagihara, R, Gajdusek, DC, Gibbs, CH Jr, Traub, R. Prospect Hill virus: serological evidence for infection in mammalogists. New Eng J Med 1984; 310: 1325–6.Google ScholarPubMed
8.Van Ypersele de Strihou, C, Méry, JP. Hantavirus-related acute interstitial nephritis in Western Europe. Expansion of a world-wide zoonosis. Quart J Med 1989; NS 73, no 270: 941–50.Google Scholar
9.Lloyd, G. Hantavirus. In: Morgan-Capner, P, ed. Current topics in clinical virology. London: Public Health Laboratory Service, 1991: 181–204.Google Scholar
10.Editorial. Hantavirus disease. Lancet 1990; 336: 407–8.CrossRefGoogle Scholar
11.Walker, E, Boyd, AJ, Kudesia, G, Pinkerton, IW. A Scottish case of nephropathy due to Hantaan virus infection. J Infect 1985; 11: 57–8.CrossRefGoogle ScholarPubMed
12. Current Notes: Hantaan Infection. Communicable Diseases: Scotland, Weekly Report. 1988; 22: No 7: 8.Google Scholar
13.Pether, JVS, Jones, N, Lloyd, G. Acute hantavirus infection. Lancet 1991; 338: 1025.CrossRefGoogle ScholarPubMed
14.Phillips, MJ, Johnson, SAN, Thomson, RK, Pether, JVS. Further UK case of acute hantavirus infection. Lancet 1991; 338: 1530–1.CrossRefGoogle ScholarPubMed
15.Pether, JVS, Thurlow, J, Palferman, TG, Lloyd, G. Acute hantavirus infection presenting as hypersensitivity vasculitis with arthropathy. J Infect 1993; 26: 75–7.CrossRefGoogle ScholarPubMed
16.Lee, PW. Immunofluorescent antibody technique. In: Lee, HW, Dalrymple, JM, eds. Manual of hemorrhagic fever with renal syndrome. WHO Collaborating Centre for Virus Reference and Research, Institute for Virus Diseases, Korea University, 1989: 77–82.Google Scholar
17.Meegan, JM, LeDuc, JW. Enzyme immunoassays. In: Lee, HW, Dalrymple, JM, eds. Manual of hemorrhagic fever with renal syndrome. WHO Collaborating Centre for Virus Reference and Research, Institute for Virus Diseases, Korea University, 1989: 83–7.Google Scholar
18.Nuti, M, Agostini, M, Albini, E, Avsic-Zupanc, T, Kraigher, A. Hantaan antibody in Italian soldiers who served in the Balkans. Lancet 1991; 338: 1277.CrossRefGoogle ScholarPubMed
19.Xiao, S, Zhu, B, Zhang, M, Zheng, T, Zheng, Z, Xiang, J. A sequential study on serum specific IgM antibody responses of patients with epidemic hemorrhagic fever and its relationship to the illness severity. Chin J Immunol 1986; 2: 218–21.Google Scholar
20.Davies, EA, Rooney, PJ, Coyle, PV, Simpson, DI, Montgomery, IW, Stanford, CF. Hantavirus and leptospira. Lancet 1988; ii: 460–1.CrossRefGoogle Scholar
21.Tkachenko, EA, Donets, MA, Rezapkin, GV, et al. Serotypes of HFRS (haemorrhagic fever with renal syndrome) virus in East European and far eastern U.S.S.R. Lancet 1982; i: 863.CrossRefGoogle Scholar
22.Lee, HW, van der Groen, G. Hemorrhagic fever with renal syndrome. In: Melnick, JL, ed. Progress in Medical Virology. Basel: Karger, 1989: 36: 62–102.Google Scholar
23.Lee, PW, Gibbs, CJ Jr, Gajdusek, DC, Yanagihara, R. Serotypic classification of hantaviruses by indirect immunofluorescent antibody and plaque reduction neutralization tests. J Clin Microbiol 1985; 22: 940–4.CrossRefGoogle ScholarPubMed
24.Dournon, E, Brion, N, Gonzalez, JP, McCormick, JB. Further case of haemorrhagic fever with renal syndrome in France. Lancet 1983; ii: 1419.CrossRefGoogle Scholar
25.Nuti, M, Messa, M, Mioni, G, Zorzenon, M, Pitzus, E. Presumed first case of haemorrhagic fever with renal syndrome in north-eastern Italy. Trans Roy Soc Trop Med Hyg 1991; 85: 789.CrossRefGoogle ScholarPubMed