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An ‘in-production’ method for testing the sterility of infusion fluids

Published online by Cambridge University Press:  15 May 2009

J. A. Rycroft  and
D. Moon
J. A. Rycroft
Affiliation:
Public Health Laboratory, Southend General Hospital, Prittlewell Chase, Southend-on-Sea
D. Moon
Affiliation:
The Pharmacy, Southend General Hospital, Prittlewell Chase, Southend-on-Sea, Essex SSO ORY
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Summary

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The addition of dehydrated broth powder to a random selection of bottles from each batch of infusion fluids before sterilization, followed by incubation of the bottles after sterilization, provides a method of sterility testing which possesses many advantages over the traditional method of culturing small samples from bottles after sterilization.

Type
Research Article
Information
Journal of Hygiene , Volume 74 , Issue 1 , February 1975 , pp. 17 - 22
Copyright
Copyright © Cambridge University Press 1975

References

REFERENCES

Department of Health (1971). Guide to Good Pharmaceutical Manufacturing Process. London: H. M. Stationery Office.Google Scholar
Department of Health (1973). Report on the Prevention of Microbial Contamination of Medical Products (Chairman: Rosenheim). London: H. M. Stationery Office.Google Scholar
Meers, P. D., Calder, M. W., Mazhar, M. M. & Lawrie, G. M. (1973). The infusion of contaminated dextrose solution, the Devonport incident. Lancet ii, 1189.CrossRefGoogle Scholar
Miles, A. A. & Misra, S. S. (1938). The estimation of the bactericidal power of the blood. Journal of Hygiene 38, 732.Google ScholarPubMed