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An inherited mild middle-aged adiposity in wild mice

Published online by Cambridge University Press:  15 May 2009

Margaret E. Wallace  and
Felicity M. Macswiney
Margaret E. Wallace
Affiliation:
Department of Genetics, University of Cambridge
Felicity M. Macswiney
Affiliation:
Department of Genetics, University of Cambridge
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Summary

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In a warfarin-resistant population of wild mice reared in the laboratory, a dominant gene for adiposity, Ad, was found to segregate. The onset of obesity is at 4–6 months, and adipose mice suffer from hyperinsulinaemia; the sexes differ in penetrance, males having greater penetrance then females. Linkage backcrosses show the gene to be situated on chromosome 7 with about 25% recombination with the closely linked warfarin-resistance genes War, and frizzy, fr. The finding of adipose in two other wild populations also carrying War is discussed as an ecological and physiological problem.

Type
Research Article
Information
Journal of Hygiene , Volume 82 , Issue 2 , April 1979 , pp. 309 - 317
Copyright
Copyright © Cambridge University Press 1979

References

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