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Aetiologies and risk factors for neonatal sepsis and pneumonia mortality among Alaskan infants

Published online by Cambridge University Press:  09 May 2005

B. D. GESSNER ,
L. CASTRODALE  and
M. SORIANO-GABARRO
B. D. GESSNER
Affiliation:
Alaska Division of Public Health, Section of Epidemiology, Anchorage, Alaska, USA
L. CASTRODALE
Affiliation:
Alaska Division of Public Health, Section of Epidemiology, Anchorage, Alaska, USA
M. SORIANO-GABARRO
Affiliation:
Meningitis and Special Pathogens Branch, US Centers for Disease Control and Prevention, Atlanta, GA, USA
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Abstract

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We evaluated all fatal neonatal sepsis and pneumonia cases occurring in Alaska during 1992–2000. Risk factors were evaluated using a database of all births occurring during the study period. Of 32 cases, group B streptococcus (GBS) was isolated from 21% (all <7 days of age), Candida spp. from 19% (all >7 days of age), non-GBS Gram-positive bacteria from 50% (53% <7 days of age), and Gram-negative infections from 38% (58% <7 days of age). Infants born at <37 weeks gestation accounted for 72% of cases and had an increased risk of GBS [rate ratio (RR) 9·1, 95% confidence interval (CI) 2·0–41] and non-GBS (RR 40, 95% CI 16–101) disease. Neonatal sepsis mortality has become an outcome concentrated among pre-term infants. Aetiologies include GBS during the early neonatal period, Candida spp. during the late neonatal period, and other bacteria during both periods.

Type
Research Article
Information
Epidemiology & Infection , Volume 133 , Issue 5 , October 2005 , pp. 877 - 881
Copyright
2005 Cambridge University Press