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Épigénétique : les écueils d’une transposition du biologique au social

Published online by Cambridge University Press:  23 April 2019

GUILLAUME PELLETIER*
Affiliation:
Université Laval

Abstract

Nous effectuons dans cet article un survol des dangers liés à certaines représentations des phénomènes épigénétiques lors de la formulation de recommandations sociales et médicales. Après avoir exploré les représentations de l’épigénétique dans différents ouvrages de vulgarisation et discours médiatiques, nous critiquons certaines des conclusions susceptibles d’émerger de tels discours qui peuvent paraître prématurées. Nous insistons en particulier sur les enjeux relevant de la responsabilité parentale —notamment celle des femmes — quant à la transmission de marqueurs épigénétiques. Enfin, nous proposons quelques considérations épistémologiques concernant la biologie du développement qui viennent nuancer la portée des discours concernant une éventuelle responsabilité épigénétique. Une telle clarification est susceptible, selon nous, de lever plusieurs difficultés relatives à la compréhension des recherches en épigénétique ainsi qu’à leur application éventuelle hors du champ scientifique.

This article offers an overview of the risks related to some representations of epigenetics in the process of making social and medical recommendations. After exploring different representations of epigenetics in popular literature and media discourses, I identify some of the premature conclusions that could emerge from such discourses, stressing issues related to parental responsibility—especially as they relate to women—regarding the transmission of epigenetic marks. I then propose some epistemological considerations regarding developmental biology in order to draw a more nuanced picture of epigenetic responsibility. I argue that such considerations are important to clarify our general understanding of epigenetic research as well as its potential translation outside the scientific area.

Type
Original Article/Article original
Copyright
Copyright © Canadian Philosophical Association 2019 

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Footnotes

Cet article a été rédigé sous la direction de Louis-Étienne Pigeon et Lyne Létourneau dans le cadre d’un projet de recherche intitulé «Programmation épigénétique et obésité : les enjeux éthiques du respect de l’autonomie et de la justice intergénérationnelle», qui a été soutenu financièrement par le Conseil de recherches en sciences humaines du Canada (CRSH).

References

Références bibliographiques

Bird, Adrian 2007 «Perceptions of Epigenetics», Nature, vol. 447, n° 7143, p. 396398.CrossRefGoogle ScholarPubMed
Borghol, Nada et al. 2012 «Associations with Early-life Socio-economic Position in Adult DNA Methylation», International Journal of Epidemiology, vol. 41, p. 6274.CrossRefGoogle ScholarPubMed
Canguilhem, Georges 2003 Du développement à l’évolution au XIXe siècle [1962], Paris, Presses universitaires de France.Google Scholar
Canguilhem, Georges 2009 Idéologie et rationalité dans l’histoire des sciences de la vie : nouvelles études d’histoire et de philosophie des sciences [1977], Paris, Vrin.Google Scholar
Carey, Nessa 2011 The Epigenetics Revolution: How Modern Biology Is Rewriting our Understanding of Genetics, Disease, and Inheritance, New York (NY), Columbia University Press.Google Scholar
Chadwick, Ruth O’Connor, et Alan 2013 «Epigenetics and Personalized Medicine: Prospects and Ethical Issues», Personalized Medicine, vol. 10, p. 463471.CrossRefGoogle ScholarPubMed
Chiapperino, Luca, Panese, Francesco et Simeoni, Umberto 2017 «L’épigénétique et le concept DOHaD. Vers de nouvelles temporalités de la médecine “personnalisée?”», Revue Médicale Suisse, vol. 13, p. 334336.Google Scholar
Daxinger, Lucia et Whitelaw, Emma 2010 «Transgenerational Epigenetic Inheritance: More Questions Than Answers», Genome Research, vol. 20, p. 16231628.CrossRefGoogle ScholarPubMed
Descola, Phillippe 2005 Par-delà nature et culture, Paris, Galimard.Google Scholar
Dolinoy, Dana C. et al. 2007 «Epigenetic Gene Regulation: Linking Early Developmental Environment to Adult Disease», Reproductive Toxicology, vol. 23, n° 3, p. 297307.CrossRefGoogle ScholarPubMed
Drake, Amanda J. et Liu, Lincoln 2010 «Intergenerational Transmission of Programmed Effects: Public Health Consequences», Trends in Endocrinology & Metabolism, vol. 21, n° 4, p. 206213.CrossRefGoogle ScholarPubMed
Drake, Amanda J. et Walker, Brian R. 2004 «The Intergenerational Effects of Fetal Programming: Non-genomic Mechanisms for the Inheritance of Low Birth Weight and Cardiovascular Risk», Journal of Endocrinology, vol. 180, p. 116.CrossRefGoogle ScholarPubMed
Dupras, Charles et Ravitsky, Vardit 2016 «Epigenetics in the Neoliberal ‘Regime of Truth’: A Biopolitical Perspective on Knowledge Translation», Hastings Center Report, vol. 46, p. 110.Google Scholar
Dupras, Charles, Ravitsky, Vardit et Williams-Jones, Bryn 2014 «Epigenetics and the Environment in Bioethics», Bioethics, vol. 8, n° 7, p. 327334.CrossRefGoogle Scholar
Ennis, Cath et Pugh, Oliver 2017 Introducing Epigenetics: A Graphic Guide, Londres, Icon books.Google Scholar
Feil, Robert et Fraga, Mario F. 2012 «Epigenetics and the Environment: Emerging Patterns and Implications», Nature Reviews Genetics, vol. 13, n° 2, p. 97109.CrossRefGoogle ScholarPubMed
Francis, Richard C. 2012 Epigenetics: How Environment Shapes Our Genes, New York (NY), W. W. Norton.Google Scholar
Fournier, Tristan et Poulain, Jean-Pierre 2017 «La génomique nutritionnelle : (re)penser les liens alimentation-santé à l’articulation des sciences sociales… », Natures Sciences Sociétés, vol. 25, n° 2, p. 111121.CrossRefGoogle Scholar
Goldberg, Aaron D., David Allis, C. et Bernstein, Emily 2007 «Epigenetics: A Landscape Takes Shape», Cell, vol. 128, p. 635638.CrossRefGoogle ScholarPubMed
Gluckman, Peter D. et Hanson, Mark A. 2004 «Living With the Past: Evolution, Development and Patterns of Disease», Science, vol. 305, n° 5691, p. 17331736.CrossRefGoogle Scholar
Guibet Lafaye, Caroline 2015 «Quelle théorie de la justice pour l’épigénétique?», Dialogue, vol. 54, p. 489517.CrossRefGoogle Scholar
Guthman, Julie et Mansfiel, Becky 2012 «The Implications of Environmental Epigenetics: A New Direction for Geographic Inquiry on Health, Space, and Nature-society Relation», Progress in Human Geography, vol. 37, n° 4, p. 486504.CrossRefGoogle Scholar
Haig, David 2012 «Commentary: The Epidemiology of Epigenetics», International Journal of Epidemiology, vol. 41, n° 1, p. 1316.CrossRefGoogle ScholarPubMed
Hanson, Mark et Müller, Ruth 2017 «Epigenetic Inheritance and the Responsibility for Health in Society», The Lancet Diabetes & Endocrinology, vol. 5, n° 1, p. 1112.CrossRefGoogle Scholar
Heard, Edith et Martienssen, Robert A. 2014 «Transgenerational Epigenetic Inheritance: Myths and Mechanisms», Cell, vol. 157, p. 95109.Google Scholar
Hedlund, Maria 2012 «Epigenetic Responsibility», Medicine Studies, vol. 3, p. 171183.CrossRefGoogle Scholar
Holliday, Robin 1987 «The Inheritance of Epigenetics Defects», Science, vol. 238, n° 4824, p. 163170.CrossRefGoogle Scholar
Holliday, Robin 2006 «Epigenetics: A Historical Overview», Epigenetics, vol. 1, n° 2, p. 7680.CrossRefGoogle ScholarPubMed
Jablonka, Eva et Lamb, Marion 2005 Evolution in Four Dimensions: Genetic, Epigenetic, Behavioral, and Symbolic Variation in the History of Life, Boston (MA), MIT press.Google Scholar
Jacob, François 1970 La logique du vivant : une histoire de l’hérédité, Paris, Gallimard.Google Scholar
Jirtle, Randy et Skinner, Michael K. 2007 «Environmental Epigenomics and Disease Susceptibility», Nature Reviews Genetics, vol. 8, p. 253262.CrossRefGoogle ScholarPubMed
Juengst, Eric T. et al. 2014 «Serving Epigenetics Before Its Time», Trends in Genetics, vol. 30, n° 10, p. 427429.CrossRefGoogle ScholarPubMed
Keller, Evelyn Fox 2003 Le siècle du gène, Paris, Galimard.Google Scholar
Keller, Evelyn Fox 2010 The Mirage of a Space Between Nature and Culture, Durham (NC), Duke University Press.CrossRefGoogle Scholar
Lake, Amelia et Townhend, Tim 2006 «Obesogenic Environments: Exploring the Built and Food Environments», The Journal of The Royal Society for the Promotion of Health, vol. 126, n° 6, p. 262267.CrossRefGoogle ScholarPubMed
Lambert, Nelle 2014 «Génétique et transmission transgénérationnelle», Cahiers de psychologie clinique, vol. 43, p. 1128.CrossRefGoogle Scholar
Landecker, Hannah et Panofsky, Aaron 2013 «From Social Structure to Gene Regulation, and Back: A Critical Introduction to Environmental Epigenetics for Sociology», Annual Review of Sociology, vol. 3, p. 333357.CrossRefGoogle Scholar
Lane, Michelle, Robker, Rebecca L. et Robertson, Sarah A. 2014 «Parenting from Before Conception», Science, vol. 345, n° 6198, p. 756760.CrossRefGoogle ScholarPubMed
Loi, Michele, Del Savio, Lorenzo et Stupka, Elia 2013 «Social Epigenetics and Equality of Opportunity», Public Health Ethics, vol. 6, n° 2, p. 142153.CrossRefGoogle ScholarPubMed
McGuiness, Dagmara et al. 2012 «Socio-economic Status Is Associated with Epigenetic Differences in the pSoBid Cohort», International Journal of Epidemiology, vol. 41, n° 1, p. 151160.CrossRefGoogle Scholar
Meloni, Maurizio 2015 «Epigenetics for the Social Sciences: Justice, Embodiment, and Inheritance in the Postgenomic Age», New Genetics and Society, vol. 34, n° 2, p. 125151.CrossRefGoogle Scholar
Meloni, Maurizio et Testa, Giuseppe 2014 «Scrutinizing the Epigenetics Revolution», BioSocieties, vol. 9, n° 4, p. 431456.CrossRefGoogle ScholarPubMed
Morange, Michel 2005 «Quelle place pour l’épigénétique?», Médecine/Sciences, vol. 21, p. 367369.CrossRefGoogle Scholar
Morange, Michel 2014 «L’épigénétique», Études, vol. 11, p. 4555.Google Scholar
Moss, Lenny 2003 What Genes Can’t Do, Boston (MA), MIT press.Google Scholar
Nelkin, Dorothy et Lindee, M. Susan 2004 The DNA Mystique: The Gene as a Cultural Icon, Ann Arbor (MI), University of Michigan Press.CrossRefGoogle Scholar
Nicoglou, Antonine 2017 «The Concept of Plasticity in the History of the Nature-Nurture Debate in the Early Twentieth Century», The Palgrave Handbook of Biology and Society, p. 97122.Google Scholar
Nicoglou, Antonine 2018 «Waddington’s Epigenetics or the Pictorial Meaning of Development and Genetics», History and Philosophy of the Life Sciences, vol. 40, n° 61.CrossRefGoogle ScholarPubMed
Nicoglou, Antonine et Merlin, Francesca 2017 «Epigenetics: A Way to Bridge the Gap Between Biological Fields», Studies in History and Philosophy of Biological and Biomedical Science, vol. 66, p. 7382.CrossRefGoogle ScholarPubMed
Parlee, Sebastian D. et MacDougald, Ormond A. 2014 «Maternal Nutrition and Risk of Obesity in Offspring: The Trojan Horse of Developmental Plasticity», BBA, Molecular Basis of Disease, vol. 1842, n° 3, p. 495506.CrossRefGoogle ScholarPubMed
Perbal, Laurence 2011 Gènes et comportement à l’ère post-génomique, Paris, Vrin.Google Scholar
Pickersgill, Martyn 2015 «Neuroscience, Epigenetics and the Intergenerational Transmission of Social Life: Exploring Expectations and Engagement», Families Relationships and Societies, vol. 3, n° 3, p. 481484.CrossRefGoogle Scholar
Pickersgill, Martyn 2016 «Epistemic Modesty, Ostentatiousness and the Uncertainties of Epigenetics: On the Knowledge Machinery of (Social) Science», The Sociological Review Monographs, vol. 64, n° 1, p. 186202.CrossRefGoogle ScholarPubMed
Pigliucci, Massimo 2001 Phenotypic Plasticity: Beyond Nature and Nurture, Baltimore (MD), Johns Hopkins University Press.Google Scholar
Pigliucci, Massimo 2009 «Avons-nous besoin d’une synthèse évolutive étendue?», dans Heams, Thomas, Huneman, Phillippe, Lecointre, Guillaume et Silberstein, Marc, dir., Les mondes darwiniens : l’évolution de l’évolution, Paris, Syllepse, p. 685701.Google Scholar
Ptashne, Mark 2007 «On the Use of the Word “Epigenetic”», Current Biology, vol. 17, n° 7, p. 233236.CrossRefGoogle ScholarPubMed
Richardson, Sarah S. et al. 2014 «Society: Don’t Blame the Mothers», Nature, vol. 512, p. 311312.CrossRefGoogle ScholarPubMed
Robison, Shea 2015 «The Shape of Things : Obesity, Political Ideology, and the Emerging Narrative of Epigenetics», Midwest Political Science Association Annual Conference, Idaho State University, 4/18/2015.Google Scholar
Rothstein, Mark A., Cai, Yu et Marchant, Gary E. 2009 «Ethical Implications of Epigenetic Research», Nature Reviews Genetics, vol. 10, n° 4, p. 224.CrossRefGoogle Scholar
Seitz, Stefanie B. et Schuol, Sebastian 2017 «State of the Public Discourse on Epigenetics», Heil, dans Reinhard et al., dir., Epigenetics: Ethical, Legal and Social Aspects, Wiesbaden, Springer VS, p. 109120.CrossRefGoogle Scholar
Stelmach, Aleksandra et Nerlich, Brigitte 2015 «Metaphors in Search of a Target: The Curious Case of Epigenetics», New Genetics and Society, vol. 34, n° 2, p. 196218.CrossRefGoogle ScholarPubMed
Stotz, Karola et Griffiths, Paul 2016 «Epigenetics: Ambiguities and Implications», History and Philosophy of the Life Sciences, vol. 38, n° 22.CrossRefGoogle ScholarPubMed
Tammen, Stephanie A., Friso, Simonetta et Choi, Sang-Woon 2013 «Epigenetics: The Link Between Nature and Nurture», Molecular Aspects of Medicine, vol. 34, n° 4, p. 753–64.CrossRefGoogle ScholarPubMed
Tolwinsky, Kasia 2013 «A New Genetics or an Epiphenomenon? Variations in the Discourse of Epigenetics Researchers», New Genetics and Society, vol. 32, n° 4, p. 366384.CrossRefGoogle Scholar
van Dijk, Susan J. et al. 2015 «Recent Developments in the Role of Epigenetics in Obesity and Metabolic Disease», Clinical Epigenetics, vol. 7, n° 66.CrossRefGoogle ScholarPubMed
Waddington, Conrad Hal 1952 «The Evolution of Developmental Systems», Herbert, dans D. A., ed., Twentyeighth Meeting of the Australian and New Zealand Association for the Advancement of Science, Brisbane, A.H. Tucker, Government Printer Brisbane.Google Scholar
Waddington, Conrad Hal 1953 «Genetic Assimilation of an Acquired Character», Evolution, vol. 7, p. 118126.CrossRefGoogle Scholar
Waddington, Conrad Hal 1957 «The Strategy of the Genes; a Discussion of Some Aspects of Theoretical Biology», Londres, Allen & Unwin.Google Scholar
Waggoner, Miranda R. et Uller, Tobias 2015 «Epigenetic Determinism in Science and Society», New Genetics and Society, vol. 34, n° 2, p.177195.CrossRefGoogle ScholarPubMed