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Treatment of adductor spasticity with BTX-A in children with CP: a randomized, double-blind, placebo-controlled study

Published online by Cambridge University Press:  19 December 2005

Volker Mall ,
Florian Heinen ,
Andrea Siebel ,
Christoph Bertram ,
Ulrich Hafkemeyer ,
Jörg Wissel ,
Steffen Berweck ,
Fritz Haverkamp ,
Günter Nass  and
Leo Döderlein
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Volker Mall
Affiliation:
Children's University Hospital, Freiburg University, Freiburg, Germany.
Florian Heinen
Affiliation:
Department of Paediatric Neurology and Developmental Medicine, Ludwig-Maximilians-University München, München, Germany.
Andrea Siebel
Affiliation:
IPSEN-Pharma GmbH, Ettlingen, Germany.
Christoph Bertram
Affiliation:
Department of Orthopaedic Surgery, University of Cologne, Cologne, Germany.
Ulrich Hafkemeyer
Affiliation:
Department of Orthopaedic Surgery, Münster University, Münster, Germany.
Jörg Wissel
Affiliation:
Department of Neurology, University of Innsbruck, Innsbruck, Austria.
Steffen Berweck
Affiliation:
Department of Paediatric Neurology and Developmental Neuroscience, Ludwig-Maximilians-University München, München, Germany.
Fritz Haverkamp
Affiliation:
Children's University Hospital, Bonn University, Bonn, Germany.
Günter Nass
Affiliation:
Department of Child Neurology, Maulbronn, Germany.
Leo Döderlein
Affiliation:
Department of Orthopedic Surgery, University of Heidelberg, Heidelberg, Germany.
Nico Breitbach-Faller
Affiliation:
Children's Hospital, Esslingen, Germany.
Wilhelm Schulte-Mattler
Affiliation:
Department of Neurology, Regensburg University, Regensburg, Germany.
Rudolf Korinthenberg
Affiliation:
Children's University Hospital, Freiburg University, Freiburg, Germany.
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Abstract

Adductor spasticity in children with cerebral palsy (CP) impairs motor function and development. In a placebo-controlled, double-blind, randomized multicentre study, we evaluated the effects of botulinum toxin A(BTX-A) in 61 children (37 males, 24 females; mean age 6 years 1 month [SD 3y 1mo]) with CP (leg-dominated tetraparesis, n=39; tetraparesis, n=22; GMFCS level I, n=3; II, n=6; III, n=17; IV, n=29; V, n=6). Four weeks after treatment, a significant superiority of BTX-A was observed in the primary outcome measure (knee–knee distance ‘fast catch’, p=0.002), the Ashworth scale (p=0.001), and the Goal Attainment Scale (p=0.037).

Type
Original Articles
Information
Developmental Medicine and Child Neurology , Volume 48 , Issue 1 , January 2006 , pp. 10 - 13
Copyright
© 2006 Mac Keith Press

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