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Using genetic designs to identify likely causal environmental contributions to psychopathology

Published online by Cambridge University Press:  06 October 2022

Ruth Sellers ,
Lucy Riglin ,
Gordon T. Harold  and
Anita Thapar Open the ORCID record for Anita Thapar [Opens in a new window]
Ruth Sellers*
Affiliation:
Brighton & Sussex Medical School, University of Sussex, Brighton, UK
Lucy Riglin
Affiliation:
Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK Wolfson Centre for Young People’s Mental Health, Cardiff University, Cardiff, UK
Gordon T. Harold
Affiliation:
Faculty of Education, University of Cambridge, Cambridge, UK School of Medicine, Child and Adolescent Psychiatry Unit, University College Dublin, Dublin, Ireland
Anita Thapar
Affiliation:
Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK Wolfson Centre for Young People’s Mental Health, Cardiff University, Cardiff, UK
*
Corresponding author: Ruth Sellers, email: [email protected]
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Abstract

The multifactorial nature of psychopathology, whereby both genetic and environmental factors contribute risk, has long been established. In this paper, we provide an update on genetically informative designs that are utilized to disentangle genetic and environmental contributions to psychopathology. We provide a brief reminder of quantitative behavioral genetic research designs that have been used to identify potentially causal environmental processes, accounting for genetic contributions. We also provide an overview of recent molecular genetic approaches that utilize genome-wide association study data which are increasingly being applied to questions relevant to psychopathology research. While genetically informative designs typically have been applied to investigate the origins of psychopathology, we highlight how these approaches can also be used to elucidate potential causal environmental processes that contribute to developmental course and outcomes. We highlight the need to use genetically sensitive designs that align with intervention and prevention science efforts, by considering strengths-based environments to investigate how positive environments can mitigate risk and promote children’s strengths.

Keywords

environmentgeneticspsychopathologystrength-based approaches
Type
Special Issue Article
Information
Development and Psychopathology , Volume 34 , Issue 5: Special Section: Leveraging Genetically Informative Study Designs to Understand the Development and Familial Transmission of Psychopathology , December 2022 , pp. 1653 - 1665
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Copyright
© The Author(s), 2022. Published by Cambridge University Press

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