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Quantitative genetics and developmental psychopathology: Contributions to understanding normal development

Published online by Cambridge University Press:  31 October 2008

Richard D. Rende
Affiliation:
Center for Developmental and Health Genetics, College of Health and Human Development, The Pennsylvania State University, University Park
Robert Plomin
Affiliation:
Center for Developmental and Health Genetics, College of Health and Human Development, The Pennsylvania State University, University Park

Abstract

This article reviews ways in which quantitative genetic approaches to developmental psychopathology can elucidate normal development. A few examples from genetics are discussed to highlight how investigations of abnormal functioning can inform the study of normal functioning. Two topics that provide bridges between the normal and abnormal are presented in greater detail. Most important is a new quantitative genetic technique that assesses empirically genetic and environmental links between the normal and abnormal. A second topic involves quantitative genetic approaches to environmental analyses, as highlighted by the examination of nonshared environmental factors. Such examinations of the environment are essential in studies of psychopathology, and their application to abnormal development can elucidate processes of normal development. We believe that forging links between the normal and abnormal is the core task of developmental psychopathology and that quantitative genetics is not only compatible with this goal, but essential to it.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1990

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References

Beadle, G. W., & Tatum, E. L. (1941). Experimental control of developmental reaction. American Naturalist, 75, 107116.CrossRefGoogle Scholar
Bessman, S. P., Williamson, M. L., & Koch, R. (1978). Diet, genetics, and mental retardation interaction between phenylketonuric heterozygous mother and fetus to produce nonspecific diminution of IQ: Evidence in support of the justification hypothesis. Proceedings of the national Academy of Sciences, 78, 15621566.CrossRefGoogle Scholar
Bouchard, T. J. Jr, & McGue, M. (1981). Familial studies of intelligence: A review. Science, 212, 10551059.CrossRefGoogle ScholarPubMed
Cicchetti, D. (1984). The emergence of developmental psychopathology. Child Development, 55, 17.CrossRefGoogle ScholarPubMed
Cicchetti, D. (1990). An historical perspective on the discipline of developmental psychopathology. In Rolf, J., Masten, A., Cicchetti, D., Neuchterlein, K., & Weintraub, S. (Eds.), Risk and protective factors in the development of psychopathology (pp. 228). New York: Cambridge University Press.CrossRefGoogle Scholar
Cicchetti, D., & Sroufe, L. A. (1976). The relationship between affective and cognitive development in Down's syndrome infants. Child Development, 47, 920929.CrossRefGoogle ScholarPubMed
Daniels, D., Dunn, J., Furstenberg, F. F. Jr., & Plomin, R. (1985). Environmental differences within the family and adjustment differences within pairs of adolescent siblings. Child Development, 56, 764774.CrossRefGoogle ScholarPubMed
DeFries, J. C., & Fulker, D. W. (1985). Multiple regression analysis of twin data. Behavior Genetics, 15, 467473.CrossRefGoogle ScholarPubMed
DeFries, J. C., & Fulker, D. W. (1988). Multiple regression analysis of twin data: Etiology of deviant scores versus individual differences. Acta Geneticae Medicae et Gemellologiae, 37, 205216.CrossRefGoogle ScholarPubMed
DeFries, J. C., Fulker, D. W., & LaBuda, M. C. (1987). Evidence for a genetic aetiology in reading disability in twins. Nature, 329, 537539.CrossRefGoogle Scholar
Dunn, J., & Plomin, R. (1990). Separate lives: Why siblings are so different. New York: Basic.Google Scholar
Dunn, J., Stocker, C., & Plomin, R. (1990). Non-shared experiences within the family: Correlates of behavioral problems in middle childhood. Development and Psychopathology, 2, 113126.CrossRefGoogle Scholar
Edelbrock, C. (1990). HDFS Colloquim. Penn State University, University Park. 03 5.Google Scholar
Falconer, D. S. (1981). Introduction to quantitative genetics (2nd ed.). London: Longman.Google Scholar
Folstein, S. E., & Rutter, M. (1988). Autism: Familial aggregation and genetic implications. Journal of Autism and Developmental Disorders, 18, 330.CrossRefGoogle ScholarPubMed
Garmezy, N. (1986). Children's responses to separation and loss: developmental aspects. In Rutter, M., Izard, C., & Read, P. (Eds.), Depression in young people: developmental and clinical perspectives. New York: Guilford.Google Scholar
Gatz, M., Pedersen, N. L., & Harris, J. (1987). Measurement characteristics of the mental health scale from the OARS. Journal of Gerontology, 42, 332335.CrossRefGoogle ScholarPubMed
Gottesman, I. I., & Bertelsen, A. (1989). Confirming unexpressed genotypes for schizophrenia. Archives of General Psychiatry, 46, 867872.CrossRefGoogle ScholarPubMed
Gottesman, I. I., & Shields, J. (1982). Schizophrenia: The epigenetic puzzle. Cambridge: Cambridge University Press.Google Scholar
Kamin, L. (1974). The science and politics of I.Q. New York: Wiley.Google ScholarPubMed
Kovacs, M. (1983). Children's Depression Inventory: A self-rated depression scale for school-aged youngsters. Unpublished manuscript, University of Pittsburg.Google Scholar
McGuffin, P. (1987). The new genetics and childhood psychiatric disorder. Journal of Child Psychology and Psychiatry, 28, 215222.CrossRefGoogle ScholarPubMed
McKusick, V. A. (1988). Mendelian inheritance in man (9th ed.). Baltimore: Johns Hopkins University Press.Google Scholar
Nichols, P. L. (1984). Familial mental retardation. Behavior Genetics, 14, 161170.CrossRefGoogle ScholarPubMed
Plomin, R. (1986). Development, genetics, and psychology. Hillsdale, NJ: Erlbaum.Google Scholar
Plomin, R. (1990a). Nature and nurture. Pacific Grove: University of California Press.Google Scholar
Plomin, R. (1990b). The role of inheritance in behavior. Science, 248, 183188.CrossRefGoogle ScholarPubMed
Plomin, R. (in press). Genetic risk and psychosocial disorders: Links between the normal and abnormal. In Rutter, M. & Casaer, P. (Eds.), Biological risk factors for psychosocial disorders. Cambridge: Cambridge University Press.Google Scholar
Plomin, R., & Daniels, D. (1987). Why are children in the same family so different from each other? Behavioral and Brain Sciences, 10, 116.CrossRefGoogle Scholar
Plomin, R., Nitz, K., & Rowe, D. C. (1990). Behavioral genetics and aggressive behavior in childhood. In Lewis, M. & Miller, S. (Eds.), Handbook of developmental psychopathology. New York: Plenum.Google Scholar
Plomin, R., & Rende, R. (in press). Human behavioral genetics. Annual Review of Psychology.Google Scholar
Plomin, R., Rende, R. D., & Rutter, M. L. (in press). Quantitative genetics and developmental psychopathology. In Cicchetti, D. & Toth, S. (Eds.), Rochester Symposium on Developmental Psychopathology (Vol. 2). Hillsdale, NJ: Erlbaum.Google Scholar
Reiss, D., Hetherington, E. M., & Plomin, R. (1991). The separate worlds of teenage siblings: An introduction to the study of the nonshared environment and adolescent development. Manuscript in preparation.Google Scholar
Reitsma-Street, M., Offord, D. R., & Finch, T. (1985). Pairs of same-sexed siblings discordant for antisocial behavior. British Journal of Psychiatry, 146, 415423.CrossRefGoogle Scholar
Roberts, J. A. F. (1952). The genetics of mental deficiency. Eugenics Review, 44, 7183.Google ScholarPubMed
Rutter, M. (1985). Resilience in the face of adversity. British Journal of Psychiatry, 147, 598611.CrossRefGoogle ScholarPubMed
Rutter, M. (1986). Child psychiatry: The interface between clinical and developmental research. Psychological Medicine, 16, 151160.CrossRefGoogle ScholarPubMed
Rutter, M. (1988). Epidemiological approaches to developmental psychopathology. Archives of General Psychiatry, 45, 486495.CrossRefGoogle ScholarPubMed
Rutter, M., Macdonald, H., Le Couteur, A., Harrington, R., Bolton, P., & Bailey, A. (1990). Genetic factors in child psychiatric disorders-II. Empirical findings. Journal of Child Psychology and Psychiatry, 31, 3982.CrossRefGoogle ScholarPubMed
Smith, C. (1974). Concordance in twins: Methods and interpretation. American Journal of Human Genetics, 26, 454466.Google ScholarPubMed