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Contributions of magnetic resonance spectroscopy to understanding development: Potential applications in the study of adolescent alcohol use and abuse

Published online by Cambridge University Press:  12 March 2014

Julia E. Cohen-Gilbert ,
J. Eric Jensen  and
Marisa M. Silveri
Julia E. Cohen-Gilbert*
Affiliation:
Neurodevelopmental Laboratory on Addictions and Mental Health McLean Hospital Harvard Medical School
J. Eric Jensen
Affiliation:
McLean Hospital Harvard Medical School
Marisa M. Silveri
Affiliation:
Neurodevelopmental Laboratory on Addictions and Mental Health McLean Hospital Harvard Medical School
*
Address correspondence and reprint requests to: Julia E. Cohen-Gilbert, McLean Imaging Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478; E-mail: [email protected].
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Abstract

A growing body of research has documented structural and functional brain development during adolescence, yet little is known about neurochemical changes that occur during this important developmental period. Magnetic resonance spectroscopy (MRS) is a well-developed technology that permits the in vivo quantification of multiple brain neurochemicals relevant to neuronal health and functioning. However, MRS technology has been underused in exploring normative developmental changes during adolescence and the onset of alcohol and drug use and abuse during this developmental period. This review begins with a brief overview of normative cognitive and neurobiological development during adolescence, followed by an introduction to MRS principles. The subsequent sections provide a comprehensive review of the existing MRS studies of development and cognitive functioning in healthy children and adolescents. The final sections of this article address the potential application of MRS in identifying neurochemical predictors and consequences of alcohol use and abuse in adolescence. MRS studies of adolescent populations hold promise for advancing our understanding of neurobiological risk factors for psychopathology by identifying the biochemical signatures associated with healthy brain development, as well as neurobiological and cognitive correlates of alcohol and substance use and abuse.

Type
Regular Articles
Information
Development and Psychopathology , Volume 26 , Issue 2 , May 2014 , pp. 405 - 423
Copyright
Copyright © Cambridge University Press 2014 

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