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Child maltreatment, adaptive functioning, and polygenic risk: A structural equation mixture model

Published online by Cambridge University Press:  06 March 2019

Eric L. Thibodeau ,
Katherine E. Masyn ,
Fred A. Rogosch  and
Dante Cicchetti
Eric L. Thibodeau*
Affiliation:
University of Minnesota
Katherine E. Masyn
Affiliation:
Georgia State University
Fred A. Rogosch
Affiliation:
Mt. Hope Family Center, University of Rochester
Dante Cicchetti*
Affiliation:
University of Minnesota Mt. Hope Family Center, University of Rochester
*
Address correspondence and reprint requests to: Eric L. Thibodeau or Dante Cicchetti, Institute of Child Development, University of Minnesota, 51 E. River Road, Minneapolis, MN 55455; E-mail: [email protected]; [email protected].
Address correspondence and reprint requests to: Eric L. Thibodeau or Dante Cicchetti, Institute of Child Development, University of Minnesota, 51 E. River Road, Minneapolis, MN 55455; E-mail: [email protected]; [email protected].
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Abstract

This study used a structural equation mixture model to examine associations between child maltreatment, polygenic risk, and indices of adaptive functioning. Children aged 6 to 13 years (N = 1,004), half maltreated, half nonmaltreated, were recruited to attend a research day camp. Multi-informant indicators of prosocial behavior, antisocial behavior, withdrawn behavior, and depression were collected and used in a latent class analysis. Four classes emerged, characterizing “well-adjusted,” “externalizing,” “internalizing,” and “socially dominant” groups. Twelve genetic variants, previously reported in the Gene × Environment literature, were modeled as one weighted polygenic risk score. Large main effects between maltreatment and adaptive functioning were observed (Wald = 35.3, df = 3, p < .0001), along with evidence of a small Gene × Environment effect (Wald = 13.5, df = 3, p = .004), adjusting for sex, age, and covariate interaction effects.

Type
Regular Articles
Information
Development and Psychopathology , Volume 31 , Issue 2 , May 2019 , pp. 443 - 456
Copyright
Copyright © Cambridge University Press 2019 

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Footnotes

Eric L. Thibodeau is now a postdoctoral research associate in the Psychology Department at the University of Minnesota.

Funding received from the National Institute on Drug Abuse (R01DA17741), the National Institute of Mental Health (R01MH083979), the Jacobs Foundation, and the Spunk Fund, Inc., awarded to Dante Cicchetti supported this research. We wish to acknowledge Ann Masten, Gerald August, Kathleen Thomas, and William Oetting for critiquing the manuscript.

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