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Interaction of serotonin transporter linked polymorphic region and childhood neglect on criminal behavior and substance use for males and females

Published online by Cambridge University Press:  31 January 2012

Jamie Vaske ,
Jamie Newsome  and
John Paul Wright
Jamie Vaske*
Affiliation:
Western Carolina University
Jamie Newsome
Affiliation:
University of Cincinnati
John Paul Wright
Affiliation:
University of Cincinnati
*
Address correspondence and reprint requests to: Jamie Vaske, Department of Criminology and Criminal Justice, Western Carolina University, 410 A Belk, Cullowhee, NC 28723; E-mail: [email protected].
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Abstract

Childhood neglect has been cited as a risk factor for later substance abuse and criminal behavior. However, a large body of literature shows that a substantial percentage of neglected and abused individuals do not go on to abuse substances or engage in criminal behavior. The current study investigates whether a genetic variant (serotonin transporter linked polymorphic region [5-HTTLPR]) in the 5-hydroxytryptamine (5-HTT) gene moderates the effect of childhood neglect on alcohol use problems, marijuana use, and criminal behavior. Data from the National Longitudinal Study of Adolescent Health shows that 5-HTTLPR conditions the effect of neglect on marijuana use for females, but not for males. Findings also reveal a significant gene–environment correlation between 5-HTTLPR and neglect for females only. These results suggest that 5-HTTLPR is associated with an increased risk of neglect for females, and it also increases neglected females’ risk of abusing marijuana.

Type
Regular Articles
Information
Development and Psychopathology , Volume 24 , Issue 1 , February 2012 , pp. 181 - 193
Copyright
Copyright © Cambridge University Press 2012

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