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Volume 30 - 2025

Contents

Review

  • MDMA-assisted therapy: challenges, clinical trials, and the future of MDMA in treating behavioral disorders

  • Steve O’Brien, David Nutt
  • Published online by Cambridge University Press:
    30 January 2025, e15
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  • This chapter explores the complex and controversial path of MDMA-assisted therapy (MDMA-AT) for treating post-traumatic stress disorder (PTSD) and other behavioral disorders. It covers MDMA’s history from research to recreation to medicine, the pivotal trials, and the challenges faced by researchers. Despite recent setbacks for the clinical application of MDMA, the chapter argues that it holds potential for transforming psychiatry and discusses the uncertain future amidst ongoing debates over ethics, methodology, and political influence.